Evidence map›Paper›PMID 34418979›Full record

ArticleBMC infectious diseases2021

Pseudoaneurysm of the ascending aorta: case report of a donor-derived Pseudomonas infection in a heart transplant recipient.

Szilvia Kugler, Miklós Pólos, Ákos Király, Ákos Pataki, Ádám Koppányi, Tamás Varga, Zsófia Szakál-Tóth, Nóra Parázs, Tímea Teszák, Zoltán Tarjányi and 5 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Szilvia KuglerHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary. kuglerszilvia92@gmail.com.
Miklós PólosHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Ákos KirályHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Ákos PatakiHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Ádám KoppányiHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Tamás VargaDepartment of Anesthesiology and Intensive Therapy, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Zsófia Szakál-TóthHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Nóra ParázsHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Tímea TeszákHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Zoltán TarjányiHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Gyula PrinzHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
István HartyánszkyHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Zoltán SzabolcsHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Béla MerkelyHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Balázs SaxHeart and Vascular Center, Semmelweis University, 68 Városmajor Street, 1122, Budapest, Hungary.
Semmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMycotic aortic pseudoaneurysm is a rare complication after heart transplantation (HTX) with remarkable mortality. Intrathoracic infection is a well-documented predisposing factor for this disease. Staphylococcus aureus, Pseudomonas aeruginosa or Candida species are commonly isolated from resected specimens of the pseudoaneurysms. We demonstrate a unique case of mycotic pseudoaneurysm caused by presumably donor-derived Pseudomonas infection in a heart transplant recipient. CASE PRESENTATION: Our 67-year-old male patient treated with diabetes mellitus underwent HTX. The donor suffered from epiglottic abscess and pneumonia with known microorganisms including Pseudomonas, therefore both the donor and recipient received targeted antimicrobial therapy and prophylaxis. Five months after the uneventful HTX, lab test of the asymptomatic patient showed moderate, increasing C-reactive protein level without obviuos source of infection. Chest computed tomography showed a large (90 mm) saccular dilatation of the tubular portion of ascending aorta. Urgent surgical intervention identified a pseudoaneurysm, histological examinations and cultures of the resected aorta verified Pseudomonas aeruginosa aortitis, while all blood cultures remained negative. Retrospective interrogation of other transplanted organs of the donor supported donor-derived infection as the transport fluid of the right kidney grew Pseudomonas. The patient received 3 weeks of ceftazidime followed by 7 months of oral ciprofloxacin therapy. One year after the operation the patient was asymptomatic with normal inflammatory markers.

conclusionsDonor-derived infection is a rare but potential cause of aortitis. Early diagnosis, surgical intervention and adjuvant antibiotic therapy seem to be the keys to successful management of mycotic pseudoaneurysms after HTX.

Indexed as

Aneurysm, FalseAneurysm, InfectedHeart TransplantationPseudomonas InfectionsAgedAortaHumansMaleRetrospective StudiesAortic pseudoaneurysmCase reportDonor-derived infectionHeart transplantationPseudomonas aeruginosa

Identifiers

PMID34418979
PMCPMC8379603
OpenAlexW3194941515

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.