Evidence map›Paper›PMID 34418964›Full record

Trial reportBMC family practice2021

"I must, and I can live with that": a thematic analysis of patients' perspectives on polypharmacy and a digital decision support system for GPs.

Robin Brünn, Beate S Müller, Benno Flaig, Petra Kellermann-Mühlhoff, Ute Karbach, Sara Söling, Christiane Muth, Marjan van den Akker, AdAM Study consortium

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC family practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03430336 (Effectiveness and Cost-effectiveness of the Application of an Electronic Medication Management Support System in Patients With Polypharmacy in General Practice), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03430336 nacompletednot on this map

Effectiveness and Cost-effectiveness of the Application of an Electronic Medication Management Support System in Patients With Polypharmacy in General Practice (AdAM).

TypeinterventionalSponsorBARMERRan2018 to 2021Enrolled12,000ConditionsPolypharmacyArmsCDSS provides drug-therapy relevant information, Modification of medication, Assessment of medication appropriateness, Medication plan, Guidance in medication process
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Communication Processes Related to Decision-Making in Medication Management Between Healthcare Providers, Older People and Their Carers: A Systematic Review.Health expectations : an international journal of public participation in health care and health policy · 2025
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 13 institutions in 3 countries.

Robin BrünnInstitute of General Practice, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. bruenn@allgemeinmedizin.uni-frankfurt.de.
Beate S MüllerInstitute of General Practice, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Benno FlaigInstitute of General Practice, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Petra Kellermann-MühlhoffBARMER Statutory Health Insurance Company, Product Strategy and Product Development, Lichtscheider Str. 89, 42285, Wuppertal, Germany.
Ute KarbachDepartment of Rehabilitation Sociology, Faculty of Rehabilitation Sciences, Technical University Dortmund, Emil-Figge-Str. 50, 44227, Dortmund, Germany.
Sara SölingInstitute for Medical Sociology, Health Services Research and Rehabilitation Science, Department of Health Services Research, University of Cologne, Eupener Str. 129, 50933, Cologne, Germany.
Christiane MuthInstitute of General Practice, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Marjan van den AkkerInstitute of General Practice, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
AdAM Study consortium
National Association of Statutory Health Insurance Physicians · DEClinical Research Consortium · USGoethe University Frankfurt · DEUniversity of Wuppertal · DEUniversity of Cologne · DERuhr University Bochum · DEBielefeld University · DEHeinrich Heine University Düsseldorf · DEHochschule Bielefeld · DEKlinikum Saarbrücken · DETU Dortmund University · DEUniversity Hospitals of the Ruhr-University of Bochum · DEZimmer Biomet (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate patients' perspectives on polypharmacy and the use of a digital decision support system to assist general practitioners (GPs) in performing medication reviews.

methodsQualitative interviews with patients or informal caregivers recruited from participants in a cluster-randomized controlled clinical trial (cRCT). The interviews were transcribed verbatim and analyzed using thematic analysis.

resultsWe conducted 13 interviews and identified the following seven themes: the patients successfully integrated medication use in their everyday lives, used medication plans, had both good and bad personal experiences with their drugs, regarded their healthcare providers as the main source of medication-related information, discussed medication changes with their GPs, had trusting relationships with them, and viewed the use of digital decision support tools for medication reviews positively. No unwanted adverse effects were reported.

conclusionsDespite drug-related problems, patients appeared to cope well with their medications. They also trusted their GPs, despite acknowledging polypharmacy to be a complex field for them. The use of a digital support system was appreciated and linked to the hope that reasons for selecting specific medication regimens would become more comprehensible. Further research with a more diverse sampling might add more patient perspectives.

trial registrationClinicalTrials.gov, NCT03430336 . Registered on February 6, 2018.

Indexed as

Drug-Related Side Effects and Adverse ReactionsGeneral PractitionersHumansPolypharmacyPrimary Health CareQualitative ResearchDecision supportInterviewsPatient perspectivePolypharmacyPrimary careQualitative study

Identifiers

PMID34418964
PMCPMC8379727
OpenAlexW3196240158

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.