Evidence map›Paper›PMID 34418857›Full record

ArticleEpilepsy research2021

Effects of hyperventilation with face mask on brain network in patients with epilepsy.

Penghui Song, Dan Cao, Siran Li, Rong Wang, Yuping Wang, Hua Lin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsy research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Penghui SongDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Geriatric Medical Research Center, Beijing, 100053, China; Beijing Key Laboratory of Neuromodulation, Beijing, 100053, China; Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100053, China.
Dan CaoBrainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
Siran LiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Rong WangCentral Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Geriatric Medical Research Center, Beijing, 100053, China.
Yuping WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Neuromodulation, Beijing, 100053, China; Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100053, China.
Hua LinDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China; Beijing Key Laboratory of Neuromodulation, Beijing, 100053, China; Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100053, China. Electronic address: linhua@ccmu.edu.cn.
Capital Medical University · CNChinese Institute for Brain Research · CNInstitute of Automation · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesDuring the ongoing pandemic of COVID-19, wearing face masks was recommended, including patients with epilepsy doing the hyperventilation (HV) test during electroencephalogram (EEG) examination somewhere. However, evidence was still limited about the effect of HV with face mask on cortical excitability of patients with epilepsy. The motivation of this work is to make use of the graph theory of EEG to characterize the cortical excitability of patients with epilepsy when they did HV under the condition wearing a surgical face mask.

methodsWe recruited 19 patients with epilepsy and 17 normal controls. All of participants completed two HV experiments, including HV with face mask (HV+) and HV without a mask (HV). The interval was 30 min and the sequence was random. Each experiment consisted of three segments: resting EEG, EEG of HV, and EEG of post-HV. EEG were recorded successively during each experiment. Participants were asked to evaluate the discomfort degree using a questionnaire when every HV is completed.

resultsAll of the participants felt more uncomfortable after HV + . Moreover, not only HV decreased small-worldness index in patients with epilepsy, but also HV + significantly increased the clustering coefficient in patients with epilepsy. Importantly, the three-way of Mask*HV*Epilepsy showed interaction in the clustering coefficient in the delta band, as well as in the path length and the small-worldness index in the theta band.

conclusionsThe results of this study indicated that patients with epilepsy showed the increased excitability of brain network during HV + . We should pay more attention to the adverse effect on brain network excitability caused by HV + in patients with epilepsy. In the clinical practice under the COVID-19 pandemic, it is important that the wearing face mask remain cautious for the individuals with epilepsy when they carried out HV behavior such as exercise (e.g., running, etc.).

Indexed as

AdultBrainCase-Control StudiesCOVID-19ElectroencephalographyEpilepsyFemaleHumansHyperventilationMaleMasksNerve NetCortical excitabilityCOVID-19ElectroencephalogramFace maskHyperventilation

Identifiers

PMID34418857
PMCPMC9759665
OpenAlexW3193403981

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.