Evidence map›Paper›PMID 34418439›Full record

SynthesisPreventive medicine2021

E-cigarette use and adverse respiratory symptoms among adolescents and Young adults in the United States.

Benjamin W Chaffee, Jessica Barrington-Trimis, Fei Liu, Ran Wu, Rob McConnell, Suchitra Krishnan-Sarin, Adam M Leventhal, Grace Kong

Open access · hybridAbstract readMeta-Analysis
In one paragraph

Synthesis in Preventive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 5 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 67 citations in OpenAlex.

  1. Pooled it
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  17. The respiratory epithelium in the era of vaping: insights fromEuropean respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  18. Understanding Reasons to Quit or Reduce Vaping and Associations With Quitting Outcomes Among High School Adolescents in Connecticut.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025
    Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Benjamin W ChaffeeCenter for Tobacco Control Research and Education, University of California San Francisco, 3333 California Street. Suite 495, San Francisco, CA 94118, United States. Electronic address: benjamin.chaffee@ucsf.edu.
Jessica Barrington-TrimisDepartment of Preventive Medicine, University of Southern California, 2001 N. Soto Street, Suite 205, Los Angeles, CA 90032, United States.
Fei LiuDepartment of Preventive Medicine, University of Southern California, 2001 N. Soto Street, Suite 205, Los Angeles, CA 90032, United States.
Ran WuDepartment of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, United States.
Rob McConnellDepartment of Preventive Medicine, University of Southern California, 2001 N. Soto Street, Suite 205, Los Angeles, CA 90032, United States.
Suchitra Krishnan-SarinDepartment of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, United States.
Adam M LeventhalDepartment of Preventive Medicine, University of Southern California, 2001 N. Soto Street, Suite 205, Los Angeles, CA 90032, United States; Department of Psychology, University of Southern California, SGM 501, 3620 S. McClintock Avenue, Los Angeles, CA 90089, United States.
Grace KongDepartment of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, United States.
University of Southern California · USYale University · USUniversity of California, San Francisco · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Center for the Study of Tobacco Product Use and Addiction (YCSTP) Project 2: Addictive Threshold of Nicotine and the Impact of SweetenersU54DA036151 · NIDA · YALE UNIVERSITY · PI LISA M FUCITO · 2018 to 2026
$41.6M
USC Tobacco Center of Regulatory ScienceU54CA180905 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam Matthew Leventhal · 2018 to 2026
$39.0M
Yale Tobacco Center of Regulatory ScienceP50DA036151 · NIDA · YALE UNIVERSITY · PI KRISHNAN-SARIN, SUCHITRA, O'MALLEY, STEPHANIE S · 2013 to 2017
$20.6M
PROJECT 5: IMPACT OF CHANGING TOBACCO PRODUCT USE ON HEALTHCARE COSTS FOR GENERAL AND VULNERABLE POPULATIONSU54HL147127 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LING, PAMELA MAY · 2018 to 2022
$20.4M
Vaping Nicotine and Cannabis Across Adolescence and Young AdulthoodR01CA229617 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BARRINGTON-TRIMIS, JESSICA LOUISE, LEVENTHAL, ADAM MATTHEW · 2019 to 2024
$4.3M
Tobacco Use Treatment Research for Vulnerable PopulationsK24DA048160 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam Matthew Leventhal · 2019 to 2026
$1.4M
NCATS NIH HHS UL1 TR001863NCI NIH HHS R01 CA229617NCI NIH HHS U54 CA180905NHLBI NIH HHS U54 HL147127NIDA NIH HHS K24 DA048160NIDA NIH HHS P50 DA036151NIDA NIH HHS U54 DA036151
6 · The paper itself

Abstract

E-cigarette use among adolescents and young adults has been associated with adverse respiratory symptoms, including symptoms of asthma and bronchitis. This investigation examined whether such associations differ by primary type of e-cigarette device used. This cross-sectional study included data from four study populations in California and Connecticut, United States, ages 13-21 years (N = 10,483), who self-reported their tobacco use behaviors and health status from 2018 to 2020. Adverse respiratory symptoms were grouped as bronchitis, asthma exacerbation, and shortness of breath. Associations with e-cigarette use were examined by frequency of e-cigarette use (regardless of device type) and most-frequently use device type in the past 30 days (pod, pen/tank, disposable, or mod). Multivariable modeling accounted for demographic variables and use of other tobacco and cannabis. Results were pooled at the study level via random-effects meta-analysis. Across the four studies, e-cigarette use >5 days/month versus never use was associated with bronchitic symptoms (summary odds ratio, sOR: 1.56; 95% confidence interval, CI: 1.37, 1.77) and shortness of breath (sOR: 1.68; 95% CI: 1.35, 2.08) but not statistically significantly with asthma exacerbations (sOR: 1.36; 95% CI; 0.95, 1.95). Among past 30-day e-cigarette users, associations with respiratory symptoms did not differ by device type. In these populations, e-cigarette use was positively associated with symptoms of bronchitis and shortness of breath, but adjusted odds of symptoms did not differ meaningfully by device type. These findings suggest that risk of these respiratory outcomes is elevated among more frequent e-cigarette users regardless of device type used.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsVapingAdolescentAdultCross-Sectional StudiesHumansTobacco UseUnited StatesYoung AdultAdolescent healthAsthmaBronchitisE-cigarettesRespiratory healthTobacco

Identifiers

PMID34418439
PMCPMC8595821
OpenAlexW3195825179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.