Evidence map›Paper›PMID 34418410›Full record

ReviewChest2022

Lung Transplantation for Patients With COVID-19.

Christopher S King, Hannah Mannem, Jasleen Kukreja, Shambhu Aryal, Daniel Tang, Jonathan P Singer, Ankit Bharat, Juergen Behr, Steven D Nathan

Open access · bronzeAbstract readReview
In one paragraph

Review in Chest, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
  2. Article
  3. Lung transplantation for interstitial lung disease.Breathe (Sheffield, England) · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Pulmonary Sequelae of Coronavirus Disease 2019.Physical medicine and rehabilitation clinics of North America · 2023
    Review
  11. Infectious Complications of Lung Transplant for Coronavirus Disease 2019-Associated Lung Injury: A Single-Center Case-Control Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  12. Article
  13. Observational
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Christopher S KingAdvanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA. Electronic address: Christopher.king@inova.org.
Hannah MannemLung Transplantation, University of Virginia, Charlottesville, VA.
Jasleen KukrejaLung Transplantation, University of California, San Francisco, CA.
Shambhu AryalAdvanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA.
Daniel TangCardiothoracic Surgery, Inova Fairfax Hospital, Falls Church, VA.
Jonathan P SingerLung Transplantation, University of California, San Francisco, CA.
Ankit BharatLung Transplantation, Northwestern Medicine, Chicago, IL.
Juergen BehrDepartment of Medicine V, University Hospital, LMU Munich, Germany.
Steven D NathanAdvanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, VA.
Inova Fairfax Hospital · USUniversity of California, San Francisco · USLMU Klinikum · DENorthwestern Medicine · USUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has caused acute lung injury in millions of individuals worldwide. Some patients develop COVID-related acute respiratory distress syndrome (CARDS) and cannot be liberated from mechanical ventilation. Others may develop post-COVID fibrosis, resulting in substantial disability and need for long-term supplemental oxygen. In both of these situations, treatment teams often inquire about the possibility of lung transplantation. In fact, lung transplantation has been successfully employed for both CARDS and post-COVID fibrosis in a limited number of patients worldwide. Lung transplantation after COVID infection presents a number of unique challenges that transplant programs must consider. In those with severe CARDS, the inability to conduct proper psychosocial evaluation and pretransplantation education, marked deconditioning from critical illness, and infectious concerns regarding viral reactivation are major hurdles. In those with post-COVID fibrosis, our limited knowledge about the natural history of recovery after COVID-19 infection is problematic. Increased knowledge of the likelihood and degree of recovery after COVID-19 acute lung injury is essential for appropriate decision-making with regard to transplantation. Transplant physicians must weigh the risks and benefits of lung transplantation differently in a post-COVID fibrosis patient who is likely to remain stable or gradually improve in comparison with a patient with a known progressive fibrosing interstitial lung disease (fILD). Clearly lung transplantation can be a life-saving therapeutic option for some patients with severe lung injury from COVID-19 infection. In this review, we discuss how lung transplant providers from a number of experienced centers approach lung transplantation for CARDS or post-COVID fibrosis.

Indexed as

Lung TransplantationCOVID-19HumansPandemicsPneumonia, ViralPulmonary FibrosisSARS-CoV-2ARDSCOVID-19lung transplantationpulmonary fibrosis

Identifiers

PMID34418410
PMCPMC8373594
OpenAlexW3195670104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.