ArticleEpilepsia2021
Anterior nucleus of the thalamus seizure detection in ambulatory humans.
Article in Epilepsia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Review
- Thalamocortical seizure onset patterns in drug-resistant focal epilepsy.Brain communications · 2026Article
- Local field potentials for target localization in centromedian deep brain stimulation for epilepsy.Frontiers in neuroscience · 2026Article
- Seizure detection using ultra-long-term subcutaneous electroencephalography: A deep learning CNN-BiLSTM approach.Epilepsia · 2026Article
- Proceedings of the 13th annual deep brain stimulation think tank: the evolving landscape.Frontiers in human neuroscience · 2026Review
- Thalamic stereoelectroencephalography: safety, accuracy, and thalamocortical connectivity.medRxiv : the preprint server for health sciences · 2025Article
- Biomarkers for Epilepsy Deep Brain Stimulation.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025Review
- Improved spatial memory for physical versus virtual navigation.Journal of neural engineering · 2025Article
- Inter-seizure variability in thalamic recruitment and its implications for precision thalamic neuromodulation.Communications medicine · 2025Article
- Invasive Neurostimulation for the Treatment of Epilepsy.Seminars in neurology · 2025Review
- Seizure Detection and Lateralization Using Thalamic Deep Brain Stimulator Recordings.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025Article
- Time series segmentation for recognition of epileptiform patterns recorded via microelectrode arrays in vitro.PloS one · 2025Article
- Modulating limbic circuits in temporal lobe epilepsy: impacts on seizures, memory, mood and sleep.Brain communications · 2025Article
- Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications.Frontiers in human neuroscience · 2025Article
- Neural signal data collection and analysis of Percept™ PC BrainSense recordings for thalamic stimulation in epilepsy.Journal of neural engineering · 2024Review
- Seizure forecasting: Bifurcations in the long and winding road.Epilepsia · 2023Review
- Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy.Annals of clinical and translational neurology · 2023Article
- An embedded intracranial seizure monitor for objective outcome measurements and rhythm identification.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023Article
- Canonical Response Parameterization: Quantifying the structure of responses to single-pulse intracranial electrical brain stimulation.PLoS computational biology · 2023Article
- Ambulatory Local Field Potential Recordings from the Thalamus in Epilepsy: A Feasibility Study.Stereotactic and functional neurosurgery · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
There is a paucity of data to guide anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS) with brain sensing. The clinical Medtronic Percept DBS device provides constrained brain sensing power within a frequency band (power-in-band [PIB]), recorded in 10-min averaged increments. Here, four patients with temporal lobe epilepsy were implanted with an investigational device providing full bandwidth chronic intracranial electroencephalogram (cEEG) from bilateral ANT and hippocampus (Hc). ANT PIB-based seizure detection was assessed. Detection parameters were cEEG PIB center frequency, bandwidth, and epoch duration. Performance was evaluated against epileptologist-confirmed Hc seizures, and assessed by area under the precision-recall curve (PR-AUC). Data included 99 days of cEEG, and 20, 278, 3, and 18 Hc seizures for Subjects 1-4. The best detector had 7-Hz center frequency, 5-Hz band width, and 10-s epoch duration (group PR-AUC = .90), with 75% sensitivity and .38 false alarms per day for Subject 1, and 100% and .0 for Subjects 3 and 4. Hc seizures in Subject 2 did not propagate to ANT. The relative change of ANT PIB was maximal ipsilateral to seizure onset for all detected seizures. Chronic ANT and Hc recordings provide direct guidance for ANT DBS with brain sensing.
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