Observational studyAnaesthesia2022
Effects of surgery and general anaesthesia on sleep-wake timing: CLOCKS observational study.
Observational study in Anaesthesia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Effect of Intraoperative Intravenous Infusion of Esketamine Combined with Dexmedetomidine on Postoperative Sleep Disturbance in Patients Undergoing Radical Mastectomy.Drug design, development and therapy · 2025Trial
- The Impact of Anesthetic Management Under Bispectral Index Monitoring on the Early Recovery Quality of Elderly Patients Undergoing Laparoscopic Surgery: A Blinded Randomized Controlled Trial.Clinical interventions in aging · 2025Trial
- Influence of Intravenous Norepinephrine Administration on Melatonin Plasma Concentration in Awake and Anaesthetised Healthy Adult Volunteers.Journal of pineal research · 2026Article
- Astrocyte-centered temporal resilience at the brain-behavior-immunity interface: sleep-circadian disruption and perioperative cognitive vulnerability in older adults.Brain, behavior, & immunity - health · 2026Review
- The implications of circadian rhythms for anaesthesia.BJA education · 2026Review
- Quantifying sleep wake rhythms in the hospital environment with digital technologies.NPJ digital medicine · 2026Article
- Mapping the Global Surge in Postoperative Sleep Research From 2014 to 2024: Bibliometric Analysis.Interactive journal of medical research · 2026Article
- Evaluating perioperative self-reported sleep quality in patients with a gynecologic malignancy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Circadian variation of post-operative complications in lung resection surgery.Frontiers in physiology · 2026Article
- Development and validation of a nomogram for prediction postoperative sleep disorders in patients with oral cancer: a prospective study.Frontiers in oncology · 2026Article
- Effects of anaesthesia and surgery on sleep-wake timing and subjective sleep quality in children: an observational study.Anaesthesia · 2025Observational
- Quantifying Sleep-Wake Rhythms in the Hospital Environment with Digital Technologies.medRxiv : the preprint server for health sciences · 2025Article
- [Cannabidiol regulates circadian rhythm to improve sleep disorders following general anesthesia in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Review
- Chronotype, cognitive outcomes, and neural dynamics: recent evidence and potential mechanisms with implications for perioperative period.Frontiers in neuroscience · 2025Review
- Effects of Dexmedetomidine as an Adjuvant in Preoperative Ultrasound-Guided Internal Branch of Superior Laryngeal Nerve Block on Postoperative Sore Throat and Hemodynamics in Patients With Double-Lumen Endotracheal Intubation: A Randomized Controlled Trial.Journal of pain research · 2025Article
- The effect of remimazolam and propofol on post-hysteroscopy sleep quality under general anesthesia: aFrontiers in pharmacology · 2025Article
- Effect of Neoadjuvant Immunochemotherapy on Postoperative Pulmonary Complications for Locally Advanced Esophageal Cancer: A Propensity Score Matching Cohort Study.Drug design, development and therapy · 2025Article
- Postoperative circadian patterns in wearable sensor measured heart rate: a prospective observational study.Journal of clinical monitoring and computing · 2024Observational
- Effect of General Anesthesia vs Regional Anesthesia on Sleep Disturbance in Elderly Patients After Discharge from the Hospital for 3 Months.Nature and science of sleep · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgery and general anaesthesia have the potential to disturb the body's circadian timing system, which may affect postoperative outcomes. Animal studies suggest that anaesthesia could induce diurnal phase shifts, but clinical research is scarce. We hypothesised that surgery and general anaesthesia would result in peri-operative changes in diurnal sleep-wake patterns in patients. In this single-centre prospective cohort study, we recruited patients aged ≥18 years scheduled for elective surgery receiving ≥30 min of general anaesthesia. The Munich Chronotype Questionnaire and Pittsburgh Sleep Quality Index were used to determine baseline chronotype, sleep characteristics and sleep quality. Peri-operative sleeping patterns were logged. Ninety-four patients with a mean (SD) age of 52 (17) years were included; 56 (60%) were female. The midpoint of sleep (SD) three nights before surgery was 03.33 (55 min) and showed a phase advance of 40 minutes to 02.53 (67 min) the night after surgery (p < 0.001). This correlated with the midpoint of sleep three nights before surgery and was not associated with age, sex, duration of general anaesthesia or intra-operative dexamethasone use. Peri-operatively, patients had lower subjective sleep quality and worse sleep efficiency. Disruption started from one night before surgery and did not normalise until 6 days after surgery. We conclude that there is a peri-operative phase advance in midpoint of sleep, confirming our hypothesis that surgery and general anaesthesia disturb the circadian timing system. Patients had decreased subjective sleep quality, worse sleep efficiency and increased daytime fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.