Evidence map›Paper›PMID 34418057›Full record

ArticleBiostatistics (Oxford, England)2023

Estimation for the bivariate quantile varying coefficient model with application to diffusion tensor imaging data analysis.

Matthew Pietrosanu, Haoxu Shu, Bei Jiang, Linglong Kong, Giseon Heo, Qianchuan He, John Gilmore, Hongtu Zhu

Abstract read
In one paragraph

Article in Biostatistics (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Competing Risk Modeling with Bivariate Varying Coefficients to Understand the Dynamic Impact of COVID-19.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew PietrosanuDepartment of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB, T6G 2G1, Canada.
Haoxu ShuDepartment of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB, T6G 2G1, Canada.
Bei JiangDepartment of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB, T6G 2G1, Canada.
Linglong KongDepartment of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB, T6G 2G1, Canada.
Giseon HeoDepartment of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB, T6G 2G1, Canada.
Qianchuan HePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle,WA 98109, USA.
John GilmoreDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Hongtu ZhuDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Funding

Statistical Analysis of Biomedical Imaging Data in Curved SpaceR01MH086633 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI IBRAHIM, JOSEPH G · 2010 to 2018
$2.9M
Analysis of Big Data Squared in Biomedical StudiesR01MH116527 · NIMH · YALE UNIVERSITY · PI ZHANG, HEPING · 2018 to 2022
$2.3M
Methods for Analyzing Cancer Somatic Mutation DataR01CA223498 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HE, QIANCHUAN · 2018 to 2022
$2.0M
NCI NIH HHS R01 CA223498NIMH NIH HHS R01 MH086633NIMH NIH HHS R01 MH116527
6 · The paper itself

Abstract

Despite interest in the joint modeling of multiple functional responses such as diffusion properties in neuroimaging, robust statistical methods appropriate for this task are lacking. To address this need, we propose a varying coefficient quantile regression model able to handle bivariate functional responses. Our work supports innovative insights into biomedical data by modeling the joint distribution of functional variables over their domains and across clinical covariates. We propose an estimation procedure based on the alternating direction method of multipliers and propagation separation algorithms to estimate varying coefficients using a B-spline basis and an $L_2$ smoothness penalty that encourages interpretability. A simulation study and an application to a real-world neurodevelopmental data set demonstrates the performance of our model and the insights provided by modeling functional fractional anisotropy and mean diffusivity jointly and their association with gestational age and sex.

Indexed as

AlgorithmsDiffusion Tensor ImagingComputer SimulationHumansNeuroimagingAlternating direction method of multipliersDirectional quantilesEnvelopeFunctional responsesMultivariate quantilesNeurodevelopmentNeuroimagingPropagation separation

Identifiers

PMID34418057
PMCPMC10102902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.