Evidence map›Paper›PMID 34417953›Full record

ArticleBiomolecular NMR assignments2021

Resonance assignment of coiled-coil 3 (CC3) domain of human STIM1.

Agrim Gupta, Christian Manuel Kitzler, Petr Rathner, Marc Fahrner, Herwig Grabmayr, Adriana Rathner, Christoph Romanin, Norbert Müller

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecular NMR assignments, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 3 countries.

Agrim GuptaInstitute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040, Linz, Austria.ORCID 0000-0002-2518-9618
Christian Manuel KitzlerInstitute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040, Linz, Austria.
Petr RathnerInstitute of Inorganic Chemistry, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040, Linz, Austria.ORCID 0000-0001-9611-5985
Marc FahrnerInstitute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40, 4020, Linz, Austria.ORCID 0000-0002-2689-0158
Herwig GrabmayrInstitute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40, 4020, Linz, Austria.
Adriana RathnerInstitute of Inorganic Chemistry, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040, Linz, Austria.ORCID 0000-0003-2919-9407
Christoph RomaninInstitute of Biophysics, Johannes Kepler University Linz, Gruberstrasse 40, 4020, Linz, Austria.ORCID 0000-0003-3756-4136
Norbert MüllerInstitute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040, Linz, Austria. norbert.mueller@jku.at.ORCID 0000-0002-7621-3980
Johannes Kepler University of Linz · AT

Funding

Austrian Science Fund FWF P 32947Austrian Science Fund FWF P 33283Austrian Science Fund FWF W 1250
6 · The paper itself

Abstract

The protein stromal interaction molecule 1 (STIM1) plays a pivotal role in mediating store-operated calcium entry (SOCE) into cells, which is essential for adaptive immunity. It acts as a calcium sensor in the endoplasmic reticulum (ER) and extends into the cytosol, where it changes from an inactive (tight) to an active (extended) oligomeric form upon calcium store depletion. NMR studies of this protein are challenging due to its membrane-spanning and aggregation properties. Therefore follow the divide-and-conquer approach, focusing on individual domains first is in order. The cytosolic part is predicted to have a large content of coiled-coil (CC) structure. We report the

Indexed as

Neoplasm ProteinsNuclear Magnetic Resonance, BiomolecularProtein DomainsStromal Interaction Molecule 1Amino Acid SequenceHumansNeoplasm ProteinsSTIM1 protein, humanStromal Interaction Molecule 1Calcium channelCoiled-coil structureCRACStore-operated calcium entry

Identifiers

PMID34417953
PMCPMC8481183
OpenAlexW3195531233

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.