Evidence map›Paper›PMID 34417928›Full record

ArticleSports medicine - open2021

Serum Cardiac and Skeletal Muscle Marker Changes in Repetitive Breath-hold Diving.

Danilo Cialoni, Andrea Brizzolari, Nicola Sponsiello, Valentina Lancellotti, Cesare Lori, Gerardo Bosco, Alessandro Marroni, Alessandra Barassi

Open access · goldAbstract read
In one paragraph

Article in Sports medicine - open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Advances in breath-hold diving research: a state-of-the-art review.European journal of applied physiology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
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  11. Capillary Blood Recovery Variables in Young Swimmers: An Observational Case Study.International journal of environmental research and public health · 2022
    Observational
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Danilo CialoniEnvironmental Physiology and Medicine Laboratory, Department of Biomedical Sciences, University of Padua, Padua, Italy. dcialoni@daneurope.org.ORCID http://orcid.org/0000-0001-7655-1261
Andrea BrizzolariDAN Europe Research Division, Contrada Padune 11, 64026, Roseto degli Abruzzi, Italy.
Nicola SponsielloApnea Academy Research, Padua, Italy.
Valentina LancellottiCardiothoracic and Vascular Department, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy.
Cesare LoriApnea Academy Research, Padua, Italy.
Gerardo BoscoEnvironmental Physiology and Medicine Laboratory, Department of Biomedical Sciences, University of Padua, Padua, Italy.
Alessandro MarroniDAN Europe Research Division, Contrada Padune 11, 64026, Roseto degli Abruzzi, Italy.
Alessandra BarassiDepartment of Health Science, Università degli Studi di Milano, Milan, Italy.
University of Padua · ITAzienda Ospedaliera Universitaria Pisana · ITUniversity of Milan · IT

Funding

DAN Europe Research Deep research ProjectMarina Scardi "Private Donation" Memorial Sabino Scordi
6 · The paper itself

Abstract

backgroundBreath-hold diving (BH-diving) is associated to extreme environmental conditions, prolonged physical activity, and complex adaptation mechanisms to supply enough O

resultsWe found statistically significant increases of CK (T0: 136.1% p < 0.0001; T1: 138.5%, p < 0.0001), CK-MBm (T0: 145.1%, p < 0.0001; T1: 153.2%, p < 0.0001) LDH (T0: 110.4%, p < 0.0003; T1: 110.1%, p < 0.0013) in both T0 and T1 blood samples, as compared to basal value. AST showed a statistically significant increase only at T0 (106.8%, p < 0.0007) while ALT did not exhibit statistically significant changes. We did not find any changes in cTnI levels between pre-dive and post-dive samples.

conclusionsOur data seem to indicate that during a BH-diving training session, skeletal and cardiac muscles react to physical effort releasing stress-related substances. Although the peculiar nature of BH-diving makes it difficult to understand if our results are related only to exercise induced muscle adaptation or whether acute hypoxia or a response to environmental changes (pressure) play a role to explain the observed changes, further studies are needed to better understand if these biomarker changes are linked to physical exercise or to acute hypoxia, or if both conditions play a role.

Indexed as

Breath-hold divingCreatine kinaseLactate dehydrogenasePhysical activityTroponin

Identifiers

PMID34417928
PMCPMC8380208
OpenAlexW3195914254

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.