Evidence map›Paper›PMID 34417915›Full record

ArticleEJNMMI research2021

Investigation of spleen CXCR4 expression by [

Richard Lewis, Stefan Habringer, Malte Kircher, Maike Hefter, Caroline Anna Peuker, Rudolf Werner, Valëza Ademaj-Kospiri, Alexander Gäble, Wolfgang Weber, Hans-Jürgen Wester and 4 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Quantitative imaging in medicine and surgery · 2026
    Article
  3. Physiological uptake patterns of gastric lymph node stations onQuantitative imaging in medicine and surgery · 2026
    Article
  4. Review
  5. Review
  6. Reduced splenic uptake of [EJNMMI research · 2025
    Article
  7. Review
  8. CXCR4-directed PET/CT with [European journal of nuclear medicine and molecular imaging · 2024
    Article
  9. Article
  10. Theranostics in Hematooncology.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  11. CXCR4-targeted theranostics in oncology.European journal of nuclear medicine and molecular imaging · 2022
    Review
  12. Article
  13. New PET Radiotracers for the Imaging of Neuroendocrine Neoplasms.Current treatment options in oncology · 2022
    Review
  14. Reduced splenic uptake onTheranostics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Richard LewisDepartment of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Stefan HabringerDepartment of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Malte KircherNuclear Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany.
Maike HefterClinic and Policlinic for Internal Medicine III, School of Medicine, Technical University of Munich, Munich, Germany.
Caroline Anna PeukerDepartment of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.
Rudolf WernerDepartment of Nuclear Medicine, University of Würzburg, Würzburg, Germany.
Valëza Ademaj-KospiriClinic for Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Alexander GäbleNuclear Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany.
Wolfgang WeberClinic for Nuclear Medicine, School of Medicine, Technical University of Munich, Munich, Germany.
Hans-Jürgen WesterChair of Pharmaceutical Chemistry, Technical University of Munich, Garching, Germany.
Andreas BuckDepartment of Nuclear Medicine, University of Würzburg, Würzburg, Germany.
Peter HerhausClinic and Policlinic for Internal Medicine III, School of Medicine, Technical University of Munich, Munich, Germany.
Constantin Lapa *Nuclear Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany.
Ulrich Keller *Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany. ulrich.keller@charite.de.ORCID http://orcid.org/0000-0002-8485-1958
Technical University of Munich · DEHumboldt-Universität zu Berlin · DEUniversity of Augsburg · DEUniversity of Würzburg · DEGerman Cancer Research Center · DE

Funding

Deutsche Forschungsgemeinschaft SFB1335, project P3Deutsche Forschungsgemeinschaft SFB824, project C3Deutsche Forschungsgemeinschaft SFB824, project Z1
6 · The paper itself

Abstract

backgroundThe chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific positron emission tomography (PET) tracer Pentixafor ([

resultsWe investigated the hypothesis that enhanced spleen [

conclusionSpleen [

Indexed as

Clinical studiesCXCR4Molecular imagingPentixaforPETRetrospective studiesSolid tumorsSpleenUptake

Identifiers

PMID34417915
PMCPMC8380222
OpenAlexW3194346057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.