ArticleSchizophrenia bulletin2022
Impact of Comorbid Affective Disorders on Longitudinal Clinical Outcomes in Individuals at Ultra-high Risk for Psychosis.
Article in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The prevalence and influencing factors of psychotic-like experiences in children and adolescents: a meta-analysis and systematic review.European child & adolescent psychiatry · 2026Pooled it
- Meta-analytic prevalence of comorbid mental disorders in individuals at clinical high risk of psychosis: the case for transdiagnostic assessment.Molecular psychiatry · 2023Pooled it
- Decoding Psychosis Risk: Neuroanatomical Correlates of the NAPLS-2 Calculator in the PRONIA Cohort.Schizophrenia bulletin · 2026Article
- Longitudinal Trajectories of Clinical Features in Community Youth With Recurrent Psychosis Spectrum Symptoms: Findings From the Philadelphia Neurodevelopmental Cohort.Schizophrenia bulletin · 2025Article
- The impact of affective and negative symptoms on the development of psychosis in a six-year follow-up of a community-based population.Social psychiatry and psychiatric epidemiology · 2025Article
- PSYSCAN multi-centre study: baseline characteristics and clinical outcomes of the clinical high risk for psychosis sample.Schizophrenia (Heidelberg, Germany) · 2025Article
- Predicting psychotic-like experiences among adolescents: the interplay of childhood trauma, cognitive biases, neuroticism, and depression.Child and adolescent psychiatry and mental health · 2025Article
- Clinical utility of the at-risk for psychosis state beyond transition: A multidimensional network analysis.European child & adolescent psychiatry · 2025Article
- Exploring the role of TNF-α, TGF-β, and IL-6 serum levels in categorical and noncategorical models of mood and psychosis.Scientific reports · 2024Article
- Cognitive Function in Patients with Psychotic and Affective Disorders: Effects of Combining Pharmacotherapy with Cognitive Remediation.Journal of clinical medicine · 2024Article
- Association of Anxiety/Depressive Symptoms with Psychotic-like Experiences: The Moderation Effect of Sex and Resilience.Children (Basel, Switzerland) · 2024Article
- Four trajectories of 24-hour urine protein levels in real-world lupus nephritis cohorts.RMD open · 2023Article
- Ethnoracial discrimination and the development of suspiciousness symptoms in individuals at clinical high-risk for psychosis.Schizophrenia research · 2023Article
- Psychotic-like experiences in the lonely predict conspiratorial beliefs and are associated with the diet during COVID-19.Frontiers in nutrition · 2022Article
- ITAlian partnership for psychosis prevention (ITAPP): Improving the mental health of young people.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
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Authors and funding
25 authors.
Funding
Abstract
introductionDiagnoses of anxiety and/or depression are common in subjects at Ultra-High Risk for Psychosis (UHR) and associated with extensive functional impairment. Less is known about the impact of affective comorbidities on the prospective course of attenuated psychotic symptoms (APS).
methodLatent class mixed modelling identified APS trajectories in 331 UHR subjects assessed at baseline, 6, 12, and 24 months follow-up. The prognostic value of past, baseline, and one-year DSM-IV depressive or anxiety disorders on trajectories was investigated using logistic regression, controlling for confounders. Cox proportional hazard analyses investigated associations with transition risk.
results46.8% of participants fulfilled the criteria for a past depressive disorder, 33.2% at baseline, and 15.1% at one-year follow-up. Any past, baseline, or one-year anxiety disorder was diagnosed in 42.9%, 37.2%, and 27.0%, respectively. Participants were classified into one of three latent APS trajectory groups: (1) persistently low, (2) increasing, and (3) decreasing. Past depression was associated with a higher risk of belonging to the increasing trajectory group, compared to the persistently low (OR = 3.149, [95%CI: 1.298-7.642]) or decreasing group (OR = 3.137, [1.165-8.450]). In contrast, past (OR = .443, [.179-1.094]) or current (OR = .414, [.156-1.094]) anxiety disorders showed a trend-level association with a lower risk of belonging to the increasing group compared to the persistently low group. Past depression was significantly associated with a higher risk of transitioning to psychosis (HR = 2.123, [1.178-3.828]).
conclusionA past depressive episode might be a particularly relevant risk factor for an unfavorable course of APS in UHR individuals. Early affective disturbances may be used to advance detection, prognostic, and clinical strategies.
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