Evidence map›Paper›PMID 34417633›Full record

SynthesisArchives of dermatological research2022

Clinical efficacy and safety of using calcipotriol-betamethasone compounding agent for psoriasis treatment: a systematic review and meta-analysis.

Junrong Ren, Qi Zhu, Siyao Wang, Xiaolong Li, Zhen Sun, Nan Li, Jian Feng, Haining Ding, Sitong Dong, Hongmei Wang

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Archives of dermatological research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Strictinin: A Key Ingredient of Tea.Molecules (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Junrong RenDepartment of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.
Qi ZhuGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Siyao WangGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Xiaolong LiGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhen SunGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Nan LiGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Jian FengGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Haining DingGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Sitong DongSystematic Review Solutions Ltd, The Ingenuity Centre, Triumph Road, Nottingham, NG7 2TU, UK.
Hongmei WangDepartment of Dermatology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China. wanghongmeitj@126.com.
Tianjin University of Traditional Chinese Medicine · CNKleijnen Systematic Reviews (United Kingdom) · GB

Funding

Tianjin Municipal Health and health committee ZC20114
6 · The paper itself

Abstract

The main objective is to evaluate clinical efficacy and safety of using calcipotriol-betamethasone compounding agent for psoriasis treatment through a systematic review and meta-analysis. We searched MEDLINE, Embase, The Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), and WanFang Data from inception till July 31, 2020. Efficacy was evaluated based on primary outcome indicators including skin lesion improvement and overall adverse reaction rate. Secondary outcome indicators included degree of life quality improvement, clinical effectiveness rate, and specific adverse reaction rates. RevMan5.3 was used to perform the meta-analysis. 22 studies finally met our inclusion criteria for the meta-analysis. The results indicated that for short-term treatment, a sequential therapy that uses calcipotriol betamethasone compounding agent and calcipotriol improves PASI score (MD = -0.94, 95% CI - 1.38 ~ - 0.49, P < 0.0001, I

Indexed as

Dermatologic AgentsPsoriasisBetamethasoneCalcitriolDrug CombinationsHumansTreatment OutcomeBetamethasonecalcipotrieneCalcitriolDermatologic AgentsDrug CombinationsCalcipotriol betamethasone compounding agentClinical efficacyClinical safetyMeta-analysisPlaque psoriasis

Identifiers

PMID34417633
OpenAlexW3196066413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.