ArticleCommunications biology2021
Developing ovine mammary terminal duct lobular units have a dynamic mucosal and stromal immune microenvironment.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- The Metabolic-Immune Axis: Amino Acids and Immune Cell Dynamics in Mammary Gland Development and Remodeling.International journal of biological sciences · 2026Review
- Increased growth rate post-weaning affects mammary gene expression of two-year-old ewes during their second pregnancy and lactation.Journal of animal science · 2025Article
- An ovine model for investigation of the microenvironment of the male mammary gland.Journal of anatomy · 2024Article
- Immune Cell Contribution to Mammary Gland Development.Journal of mammary gland biology and neoplasia · 2024Review
- In the Murine and Bovine Maternal Mammary Gland Signal Transducer and Activator of Transcription 3 is Activated in Clusters of Epithelial Cells around the Day of Birth.Journal of mammary gland biology and neoplasia · 2024Article
- Fourteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer.Journal of mammary gland biology and neoplasia · 2023Article
- Studying Mammary Physiology and Pathology in Domestic Species Benefits Both Humans and Animals.Journal of mammary gland biology and neoplasia · 2023Article
- Bridging clinic and wildlife care with AI-powered pan-species computational pathology.Nature communications · 2023Article
- Insulin expression in β cells is reduced within islets before islet loss in diabetic cats.The Journal of small animal practice · 2022Article
- The immune environment of the mammary gland fluctuates during post-lactational regression and correlates with tumour growth rate.Development (Cambridge, England) · 2022Article
- Investigating mammary glands of lactating goats for the presence of tertiary lymphoid organs.Frontiers in immunology · 2022Article
- Adaptive Cell-Mediated Immunity in the Mammary Gland of Dairy Ruminants.Frontiers in veterinary science · 2022Review
- Development and Pathology of the Equine Mammary Gland.Journal of mammary gland biology and neoplasia · 2021Review
- The Cellular Organization of the Mammary Gland: Insights From Microscopy.Journal of mammary gland biology and neoplasia · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human breast and ovine mammary gland undergo striking levels of postnatal development, leading to formation of terminal duct lobular units (TDLUs). Here we interrogate aspects of sheep TDLU growth as a model of breast development and to increase understanding of ovine mammogenesis. The distributions of epithelial nuclear Ki67 positivity differ significantly between younger and older lambs. Ki67 expression is polarised to the leading edge of the developing TDLUs. Intraepithelial ductal macrophages exhibit periodicity and considerably increased density in lambs approaching puberty. Stromal macrophages are more abundant centrally than peripherally. Intraepithelial T lymphocytes are more numerous in older lambs. Stromal hotspots of Ki67 expression colocalize with immune cell aggregates that exhibit distinct organisation consistent with tertiary lymphoid structures. The lamb mammary gland thus exhibits a dynamic mucosal and stromal immune microenvironment and constitutes a valuable model system that provides new insights into postnatal breast development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.