ArticleMucosal immunology2021
An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium.
Article in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed.
- Am80-lipid nanoparticles serve as an enteric mucosal adjuvant following parenteral immunization with inactivated polio vaccine.Science advances · 2026Article
- Aberrant signaling in tonsillar B cells producing pathogenicFrontiers in immunology · 2026Review
- Article
- Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice.EBioMedicine · 2024Article
- The intestinal immune system and gut barrier function in obesity and ageing.The FEBS journal · 2023Review
- The Underappreciated Role of Secretory IgA in IBD.Inflammatory bowel diseases · 2023Article
- The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology.International journal of molecular sciences · 2023Review
- An epithelial cell-derived metabolite tunes immunoglobulin A secretion by gut-resident plasma cells.Nature immunology · 2023Article
- Circular RNAs in inflammatory bowel disease.Frontiers in immunology · 2023Review
- The intestine: A highly dynamic microenvironment for IgA plasma cells.Frontiers in immunology · 2023Review
- Krüppel-like factor 2: a central regulator of B cell differentiation and plasma cell homing.Frontiers in immunology · 2023Review
- Krüppel-like factor 2 controls IgA plasma cell compartmentalization and IgA responses.Mucosal immunology · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Efficient IgA transcytosis is critical for the maintenance of a homeostatic microbiota. In the canonical model, locally-secreted dimeric (d)IgA reaches the polymeric immunoglobulin receptor (pIgR) on intestinal epithelium via simple diffusion. A role for integrin αE(CD103)β7 during transcytosis has not been described, nor its expression by intestinal B cell lineage cells. We found that αE-deficient (αE
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Registered trials
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