Evidence map›Paper›PMID 34417545›Full record

ArticleJournal of exposure science & environmental epidemiology2022

Traffic-related air pollution, biomarkers of metabolic dysfunction, oxidative stress, and CC16 in children.

Amy L Zhang, John R Balmes, Liza Lutzker, Jennifer K Mann, Helene G Margolis, Tim Tyner, Nina Holland, Elizabeth M Noth, Fred Lurmann, S Katharine Hammond and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of exposure science & environmental epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Mixture analysis identifies ozone as driving factor for child asthma symptoms.The journal of allergy and clinical immunology. Global · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Air Pollution: Another Threat to HDL Function.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Amy L ZhangDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-7541-2403
John R BalmesDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Liza LutzkerDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Jennifer K MannDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Helene G MargolisDepartment of Internal Medicine, University of California, Davis, Davis, CA, USA.
Tim TynerUniversity of California, San Francisco-Fresno, Fresno, CA, USA.
Nina HollandDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Elizabeth M NothDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Fred LurmannSonoma Technology, Petaluma, CA, USA.
S Katharine HammondDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, USA.
Stephanie M HolmDivision of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, CA, USA. stephaniemholm@berkeley.edu.
Berkeley Public Health Division · USUniversity of California, San Francisco · USSonoma Technology (United States) · USUniversity of California, Davis · US

Funding

Targeted Research Training CoreT42OH008429 · OH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARRIS ADAMSON, CARISA · 2005 to 2024
$30.0M
UC Berkeley/Stanford Children's Enviromental Health CenterP01ES022849 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BALMES, JOHN R, HAMMOND, S KATHARINE · 2013 to 2018
$4.2M
Low-Cost Versatile Sampler for Personal PM Exposure by MicroenvironmentR33ES024719 · NIEHS · COLORADO STATE UNIVERSITY · PI HENRY, CHARLES S, VOLCKENS, JOHN · 2017 to 2020
$2.1M
CHAPS Cohort MaintenanceR24ES030888 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BALMES, JOHN R, HOLLAND, NINA T · 2020 to 2025
$1.9M
NIEHS NIH HHS P01 ES022849NIEHS NIH HHS R24 ES030888NIEHS NIH HHS R33 ES024719NIOSH CDC HHS T42 OH008429
6 · The paper itself

Abstract

backgroundPrevious research has revealed links between air pollution exposure and metabolic syndrome in adults; however, these associations are less explored in children.

objectiveThis study aims to investigate the association between traffic-related air pollutants (TRAP) and biomarkers of metabolic dysregulation, oxidative stress, and lung epithelial damage in children.

methodsWe conducted cross-sectional analyses in a sample of predominantly Latinx, low-income children (n = 218) to examine associations between air pollutants (nitrogen dioxide (NO

resultsHDL cholesterol showed an inverse association with NO

conclusionOur results suggest that TRAP is significantly associated with decreased HDL cholesterol in longer-term time frames and elevated 8-isoprostane in shorter-term time frames. TRAP could have the potential to influence lifelong metabolic patterns, through metabolic effects in childhood.

Indexed as

Air PollutantsAir PollutionBiomarkersChildCholesterol, HDLCross-Sectional StudiesEnvironmental ExposureGlycated HemoglobinHumansNitrogen DioxideOxidative StressParticulate MatterUteroglobinVehicle EmissionsAir PollutantsBiomarkersCholesterol, HDLGlycated HemoglobinNitrogen DioxideParticulate MatterSCGB1A1 protein, humanUteroglobinVehicle EmissionsEarly Life Childhood ExposureLow-SES PopulationsMetabolic DysregulationOxidative StressPolycyclic Aromatic HydrocarbonsTraffic-related Air Pollution

Identifiers

PMID34417545
PMCPMC8858324
OpenAlexW3194559608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.