Evidence map›Paper›PMID 34417525›Full record

ArticleScientific reports2021

Doxycycline promotes proteasome fitness in the central nervous system.

Edmund Charles Jenkins, Matthew J O'Connell, Giovanni Manfredi, Doris Germain

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Edmund Charles JenkinsDivision of Hematology/Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, 10029, USA.
Matthew J O'ConnellDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, 10029, USA.
Giovanni ManfrediFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, 10065, USA.
Doris GermainDivision of Hematology/Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, 10029, USA. doris.germain@mssm.edu.
Icahn School of Medicine at Mount Sinai · USMIND Research Institute · USTisch Cancer Institute

Funding

Mitochondria quality control in SOD1-ALSR01NS062055 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI MANFREDI, GIOVANNI · 2009 to 2019
$3.7M
Processing of lesions into DNA repair and checkpoint pathwaysR01GM124079 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI O'CONNELL, MATTHEW J · 2017 to 2023
$2.1M
Mitochondrial inter membrane space-IMS unfolded protein response in familial ALSR01NS084486 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GERMAIN, DORIS A, MANFREDI, GIOVANNI · 2014 to 2018
$1.9M
NIGMS NIH HHS R01 GM124079NINDS NIH HHS R01 NS062055NINDS NIH HHS R01 NS084486
6 · The paper itself

Abstract

Several studies reported that mitochondrial stress induces cytosolic proteostasis in yeast and C. elegans. Notably, inhibition of mitochondrial translation with doxcycyline decreases the toxicity of β-amyloid aggregates, in a C. elegans. However, how mitochondrial stress activates cytosolic proteostasis remains unclear. Further whether doxycycline has this effect in mammals and in disease relevant tissues also remains unclear. We show here that doxycycline treatment in mice drastically reduces the accumulation of proteins destined for degradation by the proteasome in a CNS region-specific manner. This effect is associated with the activation of the ERα axis of the mitochondrial unfolded protein response (UPR

Indexed as

AnimalsCentral Nervous SystemCyclic AMPDoxycyclineEstrogen Receptor alphaFemaleGene Expression RegulationMaleMiceProteasome Endopeptidase ComplexSaccharomyces cerevisiaeTranscription, GeneticUnfolded Protein ResponseCyclic AMPDoxycyclineEstrogen Receptor alphaProteasome Endopeptidase Complex

Identifiers

PMID34417525
PMCPMC8379233
OpenAlexW3163678796

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.