Evidence map›Paper›PMID 34417497›Full record

ArticleScientific reports2021

Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction.

Armando Estrada, Alejandro C Rodriguez, Georgialina Rodriguez, Alice H Grant, Yoshira M Ayala-Marin, Amy J Arrieta, Robert A Kirken

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Armando EstradaDepartment of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Alejandro C Rodriguez *Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Georgialina Rodriguez *Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Alice H Grant *Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Yoshira M Ayala-Marin *Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Amy J Arrieta *Department of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA.
Robert A KirkenDepartment of Biological Sciences, The University of Texas At El Paso, El Paso, TX, 79968, USA. rkirken@utep.edu.
The University of Texas at El Paso · US

Funding

UTEP Border Biomedical Research CenterU54MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI Gabriel Andrew Frietze · 2019 to 2026
$35.1M
TCCG12MD007592 · NIMHD · UNIVERSITY OF TEXAS EL PASO · PI KIRKEN, ROBERT A. · 2012 to 2018
$19.4M
NIMHD NIH HHS G12 MD007592NIMHD NIH HHS U54 MD007592
6 · The paper itself

Abstract

T-cell activation and cellular expansion by common gamma chain cytokines such as Interleukin-2 is necessary for adaptive immunity. However, when unregulated these same pathways promote pathologies ranging from autoimmune disorders to cancer. While the functional role of Interleukin-2 and downstream effector molecules is relatively clear, the repertoire of phosphoregulatory proteins downstream of this pathway is incomplete. To identify phosphoproteins downstream of common gamma chain receptor, YT cells were radiolabeled with [

Indexed as

Signal TransductionAdaptor Proteins, Signal TransducingAmino Acid SequenceAntibodiesCell LineCytokinesHumansInterleukin-2Interleukin Receptor Common gamma SubunitMAP Kinase Signaling SystemPeptidesPhosphorylationPhosphoserinePhosphotyrosineProtein Processing, Post-TranslationalReceptors, Antigen, T-CellAdaptor Proteins, Signal TransducingAntibodiesCRKL proteinCytokinesInterleukin-2Interleukin Receptor Common gamma SubunitPeptidesPhosphoserinePhosphotyrosineReceptors, Antigen, T-CellTOR Serine-Threonine Kinases

Identifiers

PMID34417497
PMCPMC8379229
OpenAlexW3195864309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.