Evidence map›Paper›PMID 34417458›Full record

ArticleNature communications2021

Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.

Johanna Diener, Arianna Baggiolini, Mattias Pernebrink, Damian Dalcher, Luigi Lerra, Phil F Cheng, Sandra Varum, Jessica Häusel, Salome Stierli, Mathias Treier and 7 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
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  8. Multi-stage mechanisms of tumor metastasis and therapeutic strategies.Signal transduction and targeted therapy · 2024
    Review
  9. Review
  10. Article
  11. SALL4 is a CRL3Cell death and differentiation · 2024
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance.International journal of molecular sciences · 2022
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 4 countries.

Johanna Diener *University of Zürich, Institute of Anatomy, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-7733-5904
Arianna Baggiolini *University of Zürich, Institute of Anatomy, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-2476-561X
Mattias PernebrinkWallenberg Centre for Molecular Medicine, Linköping University, Linköping, Sweden.ORCID http://orcid.org/0000-0001-5528-3405
Damian DalcherUniversity of Zürich, Department of Molecular Mechanisms of Disease, Zürich, Switzerland.
Luigi LerraUniversity of Zürich, Department of Molecular Mechanisms of Disease, Zürich, Switzerland.
Phil F ChengUniversity Hospital of Zürich, Department of Dermatology, Zürich, Switzerland.ORCID http://orcid.org/0000-0003-2940-006X
Sandra VarumUniversity of Zürich, Institute of Anatomy, Zürich, Switzerland.
Jessica HäuselUniversity of Zürich, Institute of Anatomy, Zürich, Switzerland.
Salome StierliUniversity of Zürich, Institute of Anatomy, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-4981-4107
Mathias TreierMax-Delbrück-Center for Molecular Medicine, Berlin, Germany.ORCID http://orcid.org/0000-0002-8751-1246
Lorenz StuderDevelopmental Biology, The Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0741-7987
Konrad BaslerUniversity of Zürich, Institute of Molecular Life Sciences, Zürich, Switzerland.
Mitchell P LevesqueUniversity Hospital of Zürich, Department of Dermatology, Zürich, Switzerland.
Reinhard DummerUniversity Hospital of Zürich, Department of Dermatology, Zürich, Switzerland.ORCID http://orcid.org/0000-0002-2279-6906
Raffaella SantoroUniversity of Zürich, Department of Molecular Mechanisms of Disease, Zürich, Switzerland.ORCID http://orcid.org/0000-0001-9894-2896
Claudio CantùWallenberg Centre for Molecular Medicine, Linköping University, Linköping, Sweden.ORCID http://orcid.org/0000-0003-1547-5415
Lukas SommerUniversity of Zürich, Institute of Anatomy, Zürich, Switzerland. lukas.sommer@anatomy.uzh.ch.ORCID http://orcid.org/0000-0002-1143-7908
University of Zurich · CHUniversity Hospital of Zurich · CHLinköping University · SEMemorial Sloan Kettering Cancer Center · USMax Delbrück Center · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Melanoma cells rely on developmental programs during tumor initiation and progression. Here we show that the embryonic stem cell (ESC) factor Sall4 is re-expressed in the Tyr::Nras

Indexed as

Epigenesis, GeneticAcetylationAnimalsBase SequenceCarcinogenesisCell AdhesionCell LineageCell Line, TumorCell ProliferationDNA-Binding ProteinsGene Expression ProfilingGene Expression Regulation, NeoplasticHistone Deacetylase 2HistonesHumansMelanocytesDNA-Binding ProteinsHDAC2 protein, humanHistone Deacetylase 2HistonesSALL4 protein, humanSall4 protein, mouseStem Cell FactorTranscription Factors

Identifiers

PMID34417458
PMCPMC8379183
OpenAlexW3193314715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.