Evidence map›Paper›PMID 34417327›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Tuberous Sclerosis Complex (TSC) Inactivation Increases Neuronal Network Activity by Enhancing Ca

Chihiro Hisatsune, Tadayuki Shimada, Akitoshi Miyamoto, Amy Lee, Kanato Yamagata

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Epilepsy in Patients with Gliomas.Neurologia medico-chirurgica · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. New Insights into the Regulation of mTOR Signaling via CaInternational journal of molecular sciences · 2023
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Chihiro HisatsuneLaboratory of Synaptic Plasticity, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan hisatsune-ch@igakuken.or.jp yamagata-kn@igakuken.or.jp.
Tadayuki ShimadaLaboratory of Synaptic Plasticity, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan.ORCID 0000-0001-7333-9847
Akitoshi MiyamotoLaboratory of Single-Molecule Cell Biology, Kyoto University Graduate School of Biostudies, Kyoto, 606-8501, Japan.
Amy LeeDepartment of Neuroscience, University of Texas-Austin, Austin, Texas 78712-0805.
Kanato YamagataLaboratory of Synaptic Plasticity, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan hisatsune-ch@igakuken.or.jp yamagata-kn@igakuken.or.jp.
Tokyo Metropolitan Institute of Medical Science · JPKyoto University · JPThe University of Texas at Austin · US

Funding

Calcium channels in retinal photoreceptorsR01EY026817 · NEI · UNIVERSITY OF TEXAS AT AUSTIN · PI LEE, AMY · 2017 to 2025
$4.4M
NEI NIH HHS R01 EY026817
6 · The paper itself

Abstract

Tuberous sclerosis complex (TSC) is a multisystem developmental disorder characterized by hamartomas in various organs, such as the brain, lungs, and kidneys. Epilepsy, along with autism and intellectual disability, is one of the neurologic impairments associated with TSC that has an intimate relationship with developmental outcomes and quality of life. Sustained activation of the mammalian target of rapamycin (mTOR) via

Indexed as

CalciumCalcium Channels, L-TypeCell DifferentiationHumansInduced Pluripotent Stem CellsMutationNerve NetNeuronal OutgrowthNeuronsTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteinCalciumCalcium Channels, L-TypeTSC1 protein, humanTSC2 protein, humanTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteincalciumepilepsyLTCCmTORrapamycinTSC

Identifiers

PMID34417327
PMCPMC8482857
OpenAlexW3195523245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.