Evidence map›Paper›PMID 34417262›Full record

ArticleDiabetes2021

LTB

Icaro Bonyek-Silva, Antônio Fernando Araújo Machado, Thiago Cerqueira-Silva, Sara Nunes, Márcio Rivison Silva Cruz, Jéssica Silva, Reinan Lima Santos, Aldina Barral, Pablo Rafael Silveira Oliveira, Ricardo Khouri and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Leukotrienes in Innate Immunity: Still Underappreciated after All These Years?Journal of immunology (Baltimore, Md. : 1950) · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Omicron Variant of SARS-CoV-2 Virus:Frontiers in endocrinology · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Icaro Bonyek-SilvaGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Antônio Fernando Araújo MachadoSalvador University, Salvador, Bahia, Brazil.
Thiago Cerqueira-SilvaGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Sara NunesGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Márcio Rivison Silva CruzSalvador University, Salvador, Bahia, Brazil.
Jéssica SilvaGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Reinan Lima SantosGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Aldina BarralGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Pablo Rafael Silveira OliveiraInstitute of Biological Sciences, Federal University of Bahia, Salvador, Bahia, Brazil.
Ricardo KhouriGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
C Henrique SerezaniDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Cláudia BrodskynGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Juliana Ribeiro CaldasSalvador University, Salvador, Bahia, Brazil.
Manoel Barral-NettoGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Viviane BoaventuraGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Natalia Machado TavaresGonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil natalia.tavares@fiocruz.br.ORCID 0000-0002-4026-679X
Universidade Federal da Bahia · BRUniversidade Salvador · BREscola Bahiana de Medicina e Saúde Pública · BRVanderbilt University Medical Center · US

Funding

Phosphatase and tensin homolog PTEN actions in polymicrobial sepsisR01HL124159 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEREZANI, C. HENRIQUE · 2014 to 2022
$4.2M
Prostaglandin E2 Actions and Enhanced Susceptibility to Skin Infection in Diabetic MiceR01DK122147 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEREZANI, C. HENRIQUE · 2020 to 2022
$1.7M
Mechanisms underlying poor skin host defense in diabetic conditionsR21AI149207 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEREZANI, C. HENRIQUE · 2020 to 2021
$467k
NHLBI NIH HHS R01 HL124159NIAID NIH HHS R21 AI149207NIDDK NIH HHS R01 DK122147
6 · The paper itself

Abstract

Diabetes is a known risk factor for severe coronavirus disease 2019 (COVID-19), the disease caused by the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there is a lack of knowledge about the mechanisms involved in the evolution of COVID-19 in individuals with diabetes. We aimed to evaluate whether the chronic low-grade inflammation of diabetes could play a role in the development of severe COVID-19. We collected clinical data and blood samples of patients with and without diabetes hospitalized for COVID-19. Plasma samples were used to measure inflammatory mediators and peripheral blood mononuclear cells, for gene expression analysis of the SARS-CoV-2 main receptor system (

Indexed as

SARS-CoV-2Angiotensin-Converting Enzyme 2Arachidonate 5-LipoxygenaseCOVID-19Diabetes MellitusGene Expression RegulationHumansInflammationLeukotriene B4Risk FactorsSignal TransductionACE2 protein, humanALOX5 protein, humanAngiotensin-Converting Enzyme 2Arachidonate 5-LipoxygenaseLeukotriene B4

Identifiers

PMID34417262
PMCPMC8576416
OpenAlexW3172178054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.