SynthesisBMJ open2021
Natural history of histologically confirmed high-grade cervical intraepithelial neoplasia during pregnancy: meta-analysis.
Synthesis in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Association between cervical ectropion and high-grade cervical dysplasia in women of reproductive age.BMC women's health · 2026Article
- Approaches to Intraepithelial Cervical Neoplasia Management in Pregnancy: A Narrative Review.Life (Basel, Switzerland) · 2026Review
- Silencing HPV: the rise of RNA therapeutics in cervical cancer.Infectious agents and cancer · 2026Review
- The association of post-conization pregnancy with subsequent cervical lesions: evidence from a nationwide cohort in Sweden.BMC medicine · 2025Article
- Biomarkers differentiating regression from progression among untreated cervical intraepithelial neoplasia grade 2 lesions.Journal of advanced research · 2025Review
- The significance of biological samples from pregnant women in cervical intraepithelial neoplasia.Frontiers in medicine · 2025Article
- Cervical intraepithelial neoplasia and cervical cytology in pregnancy.Journal of pathology and translational medicine · 2024Review
- Conservative management of cervical intraepithelial neoplasia 2 and prediction of its progression - a retrospective study.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to conduct a meta-analysis of estimates of the natural history of high-grade cervical intraepithelial neoplasia (CIN) during pregnancy.
settingStudies examining the clinical courses of histologically confirmed high-grade CIN during pregnancy.
participantsWe searched PubMed, Web of Science and Embase for eligible studies. Studies were included if they reported the data regarding the natural history of histologically confirmed high-grade CIN during pregnancy. Final estimates were from the meta-analysis of 10 eligible studies. PRIMARY OUTCOME MEASURES: The regression rate, persistence rate and progression rate of histologically proven untreated high-grade CIN during pregnancy.
resultsA total of 10 original studies were included in this meta-analysis. During pregnancy, the regression rate, persistence rate and progression rate of high-grade CIN were 40% (95% CI 35% to 45%), 59% (95% CI 54% to 64%) and 1% (95% CI 0% to 2%), respectively. There was moderate heterogeneity among the studies. The results of the subgroup meta-analysis show that the pooled rates of regression and persistence during pregnancy were 59% (95% CI 54% to 65%) and 40% (95% CI 35% to 45%) for CIN2, and 29% (95% CI 25% to 33%) and 70% (95% CI 65% to 73%) for CIN3.
conclusionsDuring pregnancy, the majority of histologically confirmed high-grade CIN would be persistent or regressed to lower grade CIN or normal. However, it is still worth noting that a small percentage of high-grade CIN would progress to cervical cancer during pregnancy.
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