ArticleScience advances2021
X-ray free-electron laser studies reveal correlated motion during isopenicillin
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Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
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Who cites it
35 citing papers in PubMed, 47 citations in OpenAlex.
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- The Single-Particle, Clusters and Biomolecules and Serial Femtosecond Crystallography instrument of the European X-ray Free-Electron Laser: Interaction Region Downstream at atmospheric pressure (IRD).Journal of synchrotron radiation · 2026Article
- Biocatalytic Synthesis of N-Protected α-Amino Acids through 1,3-Nitrogen Migration by Nonheme Iron Enzymes.Journal of the American Chemical Society · 2025Article
- Sample delivery methods for protein X-ray crystallography with a special focus on sample consumption.Nature communications · 2025Review
- Revealing the catalytic mechanism of the Fe(II)/2-oxoglutarate-dependent human epigenetic modifying enzyme ALKBH5.Cell reports. Physical science · 2025Article
- Macromolecular crystallography and biology at the Linac Coherent Light Source.Journal of synchrotron radiation · 2025Article
- Robust error calibration for serial crystallography.Acta crystallographica. Section D, Structural biology · 2025Article
- X-ray Absorption Spectroscopy of Dilute Metalloenzymes at X-ray Free-Electron Lasers in a Shot-by-Shot Mode.The journal of physical chemistry letters · 2025Article
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- Structural, Spectroscopic, and Computational Insights from Canavanine-Bound and Two Catalytically Compromised Variants of the Ethylene-Forming Enzyme.Biochemistry · 2024Article
- Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography.Science advances · 2024Article
- Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH.Chemical science · 2024Article
- The time revolution in macromolecular crystallography.Structural dynamics (Melville, N.Y.) · 2024Article
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Authors and funding
41 authors at 9 institutions in 5 countries.
Patrick RabeChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0002-3448-9559
Jos J A G KampsChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0001-8646-1796
Kyle D SutherlinMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.ORCID 0000-0001-6958-4671
James D S LinyardChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Pierre AllerDiamond Light Source, Diamond House, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK.
Cindy C PhamMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Hiroki MakitaMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Ian CliftonChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0001-5893-5640
Michael A McDonoughChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Thomas M LeissingChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Denis ShutinChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
Pauline A LangChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0003-3187-1469
Agata ButrynDiamond Light Source, Diamond House, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK.
Jürgen BremChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0002-0137-3226
Sheraz GulMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.ORCID 0000-0001-8920-8737
Franklin D FullerLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
In-Sik KimMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Mun Hon CheahDepartment of Chemistry - Ångström, Molecular Biomimetics, Uppsala University, SE 751 20 Uppsala, Sweden.ORCID 0000-0001-5732-1524
Thomas FranssonInterdisciplinary Center for Scientific Computing, University of Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0002-3770-9780
Asmit BhowmickMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Iris D YoungMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.ORCID 0000-0003-4713-9504
Lee O'RiordanMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.ORCID 0000-0002-6758-9433
Aaron S BrewsterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.ORCID 0000-0002-0908-7822
Ilaria PettinatiChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0002-5904-7984
Margaret DoyleMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Yasumasa JotiJapan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan.
Shigeki OwadaJapan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan.ORCID 0000-0002-1451-7612
Kensuke TonoJapan Synchrotron Radiation Research Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan.ORCID 0000-0003-1218-3759
Alexander BatyukLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.ORCID 0000-0002-9393-2880
Mark S HunterLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
Roberto Alonso-MoriLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.ORCID 0000-0002-5357-0934
Uwe BergmannStanford PULSE Institute, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.ORCID 0000-0001-5639-166X
Robin L OwenDiamond Light Source, Diamond House, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK.ORCID 0000-0002-2104-7057
Nicholas K SauterMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.ORCID 0000-0003-2786-6552
Timothy D W ClaridgeChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0001-5583-6460
Carol V RobinsonChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.ORCID 0000-0001-7829-5505
Vittal K YachandraMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.ORCID 0000-0002-3983-7858
Junko YanoMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.ORCID 0000-0001-6308-9071
Jan F KernMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA. christopher.schofield@chem.ox.ac.uk allen.orville@diamond.ac.uk jfkern@lbl.gov.ORCID 0000-0002-7272-1603
Allen M OrvilleDiamond Light Source, Diamond House, Harwell Science and Innovation Campus, Didcot OX11 0DE, UK. christopher.schofield@chem.ox.ac.uk allen.orville@diamond.ac.uk jfkern@lbl.gov.ORCID 0000-0002-7803-1777
Christopher J SchofieldChemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk allen.orville@diamond.ac.uk jfkern@lbl.gov.ORCID 0000-0002-0290-6565
Lawrence Berkeley National Laboratory · USUniversity of Oxford · GBRutherford Appleton Laboratory · GBSLAC National Accelerator Laboratory · USSPring-8 · JPDiamond Light Source · GBHeidelberg University · DEUniversity of Wisconsin–Madison · USUppsala University · SE
Funding
Taking Snapshots of the Water-Oxidation Reaction by the Mn4Ca Oxygen-Evolving Complex Using X-ray Crystallography and SpectroscopyR01GM055302 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI YACHANDRA, VITTAL · 1997 to 2022
$9.1MStructural Dynamics at LCLSP41GM139687 · NIGMS · STANFORD UNIVERSITY · PI HUNTER, MARK · 2021 to 2025
$7.5MDIALS: New Computational Methods to Enable Challenging Crystallographic ExperimentsR01GM117126 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI SAUTER, NICHOLAS K · 2016 to 2023
$6.1MBiological Spectroscopy and Crystallography Using an X-ray Free Electron Laser - Supplemental EquipmentR01GM110501 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Junko Yano · 2014 to 2026
$4.8MHigh throughput sample delivery method for time resolved studies of enzyme reactions with X-ray and complementary techniquesR01GM126289 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KERN, JAN F · 2017 to 2025
$4.6MHigh-end X-ray Detector System for Femtosecond CrystallographyS10OD023453 · OD · STANFORD UNIVERSITY · PI BOUTET, SEBASTIEN · 2017 to 2017
$1.7MStructure and Function of the Mn Oxygen-Evolving ComplexR56GM055302 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI YACHANDRA, VITTAL · 2009 to 2009
$530kQuantum refinement for improvement of metalloenzyme crystal structuresF32GM133081 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI SUTHERLIN, KYLE D. · 2019 to 2019
$48kBiotechnology and Biological Sciences Research Council BB/M011224/1Cancer Research UK 24759MRF_ MRF-145-0004-TPG-AVISONIGMS NIH HHS F32 GM133081NIGMS NIH HHS P41 GM139687NIGMS NIH HHS R01 GM055302NIGMS NIH HHS R01 GM110501NIGMS NIH HHS R01 GM117126NIGMS NIH HHS R01 GM126289NIGMS NIH HHS R56 GM055302NIH HHS S10 OD023453Wellcome Trust
Abstract
Isopenicillin
Indexed as
ElectronsOxidoreductasesCatalysisCatalytic DomainCrystallography, X-RayFerric CompoundsHumansLasersOxygenPenicillinsSubstrate SpecificityFerric CompoundsOxidoreductasesOxygenpenicillin NPenicillins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.