Evidence map›Paper›PMID 34416847›Full record

ReviewSeminars in cardiothoracic and vascular anesthesia2021

Persistent Pain After Cardiac Surgery: Prevention and Management.

James C Krakowski, Matthew J Hallman, Alan M Smeltz

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Seminars in cardiothoracic and vascular anesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07732465 (Effectiveness of Adductor Canal Block in Postoperative Co-analgesia for Cardiac Surgery With Saphenous Vein Harvesting), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07732465 phase2 / phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of Adductor Canal Block in Postoperative Co-analgesia for Cardiac Surgery With Saphenous Vein Harvesting

TypeinterventionalSponsorMontreal Heart InstituteRan2026 to 2027Enrolled120ConditionsCoronary Artery Bypass Grafting (CABG) Surgery, SaphenectomyArmsAductor canal bloc, Control adductor canal block
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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  12. A prolactin-targeting antibody to prevent stress-induced peripheral nociceptor sensitization and female postoperative pain.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

James C KrakowskiUniversity of North Carolina at Chapel Hill, NC, USA.
Matthew J HallmanUniversity of North Carolina at Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0002-4772-8141
Alan M SmeltzUniversity of North Carolina at Chapel Hill, NC, USA.ORCID https://orcid.org/0000-0001-9623-524X
University of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent postoperative pain (PPP) after cardiac surgery is a significant complication that negatively affects patient quality of life and increases health care system burden. However, there are no standards or guidelines to inform how to mitigate these effects. Therefore, in this review, we will discuss strategies to prevent and manage PPP after cardiac surgery. Adequate perioperative analgesia may prove instrumental in the prevention of PPP. Although opioids have historically been the primary analgesic approach to cardiac surgery, an opioid-sparing strategy may prove advantageous in reducing side effects, avoiding secondary hyperalgesia, and decreasing risk of PPP. Implementing a multimodal analgesic plan using alternative medications and regional anesthetic techniques may offer superior efficacy while reducing adverse effects.

Indexed as

Cardiac Surgical ProceduresQuality of LifeAnalgesics, OpioidHumansPostoperative PainAnalgesics, Opioidcardiac surgerymultimodal analgesiaopioidspersistent postoperative painpostoperative complications

Identifiers

PMID34416847
PMCPMC8669213
OpenAlexW3193504000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.