ArticleCerebral cortex (New York, N.Y. : 1991)2022
Brain and Behavioral Evidence for Reweighting of Vestibular Inputs with Long-Duration Spaceflight.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- The human brain in space: a meta-analysis of neuroimaging evidence.Frontiers in psychology · 2026Pooled it
- Effect of spaceflight experience on human brain structure, microstructure, and function: systematic review of neuroimaging studies.Brain imaging and behavior · 2024Pooled it
- Retention Effects of Long-Term Balance Training with Vibrotactile Sensory Augmentation in Healthy Older Adults.Sensors (Basel, Switzerland) · 2022Trial
- Learning Gravity: An Innately Constrained Bayesian Model of Human Vestibular Development.Audiology research · 2026Article
- An experimentally informed computational model of neurovestibular adaptation to altered gravity.Experimental physiology · 2026Article
- Neurological complications in microgravity and long duration spaceflight.NPJ microgravity · 2026Review
- Ophthalmic and Visual System Changes in Human Spaceflight: A Review of Mechanisms, Measurement, and Countermeasures.Journal of clinical medicine · 2026Review
- Brain displacement and nonlinear deformation following human spaceflight.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Data-driven vestibular fMRI in PPPD and residual dizziness after BPPV: a narrative methodological review of AI-based phenotyping and longitudinal modeling.Frontiers in neurology · 2026Review
- Dose-response and recovery trajectories of fall prevention rehabilitation in older patients with vertigo: a retrospective cohort study based on vestibular and gait impairment phenotypes.Frontiers in neurology · 2026Article
- Effects of seasonal factors on brain function: Systematic review and future perspectives.iScience · 2025Article
- Sensory network segregation as a predictor of post spaceflight balance impairments and sensory re-weighting.NPJ microgravity · 2025Article
- Neural correlates of vestibular adaptation in cosmonauts after long duration spaceflight.NPJ microgravity · 2025Article
- Spaceflight and Ground-Based Microgravity Simulation Impact on Cognition and Brain Plasticity.International journal of molecular sciences · 2025Review
- Reducing motion sickness during simulated astronaut post-spaceflight water landings using anticipatory cues or postural control.NPJ microgravity · 2025Article
- Brains in space: impact of microgravity and cosmic radiation on the CNS during space exploration.Nature reviews. Neuroscience · 2025Review
- The effect of vibrotactile feedback on performance, perception and trust when balancing in different analog g-levels.Experimental brain research · 2025Article
- Semicircular Canals Input Can Modify the Fast-Phase Nystagmus in Off-Vertical Axis Rotation of Mice.eNeuro · 2025Article
- The microgravity environment affects sensorimotor adaptation and its neural correlates.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Thirty minutes of daily artificial gravity does not mitigate head down tilt induced brain activity changes during cognitive task performance.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
Microgravity alters vestibular signaling. In-flight adaptation to altered vestibular afferents is reflected in post-spaceflight aftereffects, evidenced by declines in vestibularly mediated behaviors (e.g., walking/standing balance), until readaptation to Earth's 1G environment occurs. Here we examine how spaceflight affects neural processing of applied vestibular stimulation. We used fMRI to measure brain activity in response to vestibular stimulation in 15 astronauts pre- and post-spaceflight. We also measured vestibularly-mediated behaviors, including balance, mobility, and rod-and-frame test performance. Data were collected twice preflight and four times postflight. As expected, vestibular stimulation at the preflight sessions elicited activation of the parietal opercular area ("vestibular cortex") and deactivation of somatosensory and visual cortices. Pre- to postflight, we found widespread reductions in this somatosensory and visual cortical deactivation, supporting sensory compensation and reweighting with spaceflight. These pre- to postflight changes in brain activity correlated with changes in eyes closed standing balance, and greater pre- to postflight reductions in deactivation of the visual cortices associated with less postflight balance decline. The observed brain changes recovered to baseline values by 3 months postflight. Together, these findings provide evidence for sensory reweighting and adaptive cortical neuroplasticity with spaceflight. These results have implications for better understanding compensation and adaptation to vestibular functional disruption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.