Evidence map›Paper›PMID 34416679›Full record

ArticleDrug and alcohol dependence2021

Nicotine dependence symptoms in U.S. youth who use JUUL E-cigarettes.

Afton Kechter, Junhan Cho, Richard A Miech, Jessica L Barrington-Trimis, Adam M Leventhal

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07009509 (Pilot and Feasibility Testing of a Peer-led Program to Prevent Youth Nicotine Vaping), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07009509 narecruitingnot on this mapstarted 2024, after this paper: background citation

Pilot and Feasibility Testing of a Peer-led Program to Prevent Youth Nicotine Vaping: The YES-CAN! Program

TypeinterventionalSponsorUniversity of Colorado, DenverRan2024 to 2026Enrolled1,166ConditionsNicotine VapingArmsYES-CAN! program
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. What is the Addictive Potential from Vaping?Nordisk alkohol- & narkotikatidskrift : NAT · 2026
    Article
  4. Review
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  7. The Impact of Social Norms on Diffusion Dynamics: A Simulation of E-Cigarette Use Behavior.Health education & behavior : the official publication of the Society for Public Health Education · 2025
    Article
  8. Vaping-Specific Nicotine Dependence Across Days Among a National Sample of US Young Adults Who Vape.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  9. Article
  10. Article
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  20. Remote Versus In-Person Learning During COVID-19: Comparison of E-Cigarette Susceptibility and Ever Use Among a Diverse Cohort of 6th-Grade Students in Texas.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Afton KechterDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, United States. Electronic address: kechter@usc.edu.
Junhan ChoDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, United States.
Richard A MiechInstitute for Social Research, University of Michigan, Ann Arbor, MI, United States.
Jessica L Barrington-TrimisDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, United States.
Adam M LeventhalDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, United States; Institute for Addiction Science, University of Southern California, Los Angeles, CA, United States.
University of Southern California · USUniversity of Michigan · US

Funding

Monitoring the Future: Drug Use & Lifestyles of American Youth (Supp1: Nicotine Pouch and E-cigarette Use Among US Adolescents: National Estimates of Brand Use and Flavor Preferences)R01DA001411 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Richard A Miech · 1985 to 2026
$144.9M
USC Tobacco Center of Regulatory ScienceU54CA180905 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI John R Monterosso · 2018 to 2026
$39.0M
Vaping Nicotine and Cannabis Across Adolescence and Young AdulthoodR01CA229617 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BARRINGTON-TRIMIS, JESSICA LOUISE, LEVENTHAL, ADAM MATTHEW · 2019 to 2024
$4.3M
Tobacco Use Treatment Research for Vulnerable PopulationsK24DA048160 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam Matthew Leventhal · 2019 to 2026
$1.4M
NCI NIH HHS R01 CA229617NCI NIH HHS U54 CA180905NIDA NIH HHS K24 DA048160NIDA NIH HHS R01 DA001411
6 · The paper itself

Abstract

purposeTo estimate the prevalence, patterns, and correlates of self-reported nicotine dependence symptoms among U.S. youth who use JUUL - a widely-sold e-cigarette brand - in 2019 and compare findings to nicotine dependence symptoms in youth who smoke cigarettes.

methodsData were from a nationally-representative subsample of 8th, 10th, and 12th grade students in the Monitoring the Future Study who had used JUUL or cigarettes in the past 30 days. Participants self-reported presence/absence of 9 different nicotine dependence symptoms for JUUL or cigarettes. Weighted percentages for JUUL or cigarette nicotine dependence symptom status (≥1 vs. 0 symptoms) and severity (count, range: 0-9) were calculated. Among JUUL users, we estimated associations of sociodemographic characteristics and other substance use with nicotine dependence and severity.

resultsAmong 1,748 past 30-day JUUL users, 41.3 % screened positive for ≥1 nicotine dependence symptoms; the mean symptom count was 1.6 (SD = 2.6). Non-nicotine substance use and more frequent JUUL use was associated with significantly greater odds of dependence and more severe dependence symptoms in multivariable models. The severity distribution of most (craving) and least (inability to quit) dependence symptom types observed in JUUL dependence paralleled those observed in analysis of combustible cigarette dependence symptoms in past 30-day smokers.

conclusionA substantial proportion of U.S. adolescent JUUL users reported symptoms of nicotine dependence, which is greater for those who vape more frequently and use other substances. Nicotine dependence screening, prevention, and regulatory policies addressing use of JUUL or similar e-cigarette products should be considered to protect U.S. youth.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsTobacco Use DisorderVapingAdolescentHumansSmokersAdolescentE-cigaretteJUUL useNicotine dependence

Identifiers

PMID34416679
PMCPMC8464491
OpenAlexW3189825720

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.