Evidence map›Paper›PMID 34416305›Full record

ArticleFitoterapia2022

Investigation of red clover (Trifolium pratense) isoflavonoid residual complexity by off-line CCS-qHNMR.

Gonzalo R Malca-Garcia, Yang Liu, Dejan Nikolić, J Brent Friesen, David C Lankin, James B McAlpine, Shao-Nong Chen, Guido F Pauli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Fitoterapia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gonzalo R Malca-GarciaUIC Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA.
Yang LiuUIC Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA.
Dejan NikolićUIC Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA.
J Brent FriesenCenter for Natural Product Technologies (CENAPT), Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA; Physical Sciences Department, Rosary College of Arts and Sciences, Dominican University, 7900 W. Division Street, River Forest, IL 60305, USA.
David C LankinUIC Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA; Center for Natural Product Technologies (CENAPT), Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA.
James B McAlpineUIC Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA; Center for Natural Product Technologies (CENAPT), Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA.
Shao-Nong ChenUIC Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA; Center for Natural Product Technologies (CENAPT), Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA.
Guido F PauliUIC Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA; Center for Natural Product Technologies (CENAPT), Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 S Wood Street, Chicago, IL 60612, USA. Electronic address: gfp@uic.edu.

Funding

Van Breemen: Project 3; Botanical Dietary Supplements - Metabolism and Safety in Women (Van Breemen)P50AT000155 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PAULI, GUIDO F · 1999 to 2019
$30.4M
NCCIH NIH HHS P50 AT000155
6 · The paper itself

Abstract

The importance of Trifolium pratense L. as a dietary supplement and its use in traditional medicine prompted the preparation of a thorough metabolite profile. This included the identification and quantitation of principal constituents as well as low abundant metabolites that constitute the residual complexity (RC) of T. pratense bioactives. The purity and RC of isoflavonoid fractions from standardized red clover extract (RCE) was determined using an off-line combination of countercurrent separation (CCS) and two orthogonal analytical methodologies: quantitative

Indexed as

FlavonoidsMass SpectrometryMedicine, TraditionalPlant ExtractsPlants, MedicinalTrifoliumFlavonoidsPlant ExtractsCentrifugal partition chromatographyCountercurrent separationExternal calibrantsPreparative metabolomicsQuantitative (1)H NMR (qHNMR) spectroscopyRed clover extract

Identifiers

PMID34416305
PMCPMC8742771

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.