Evidence map›Paper›PMID 34416191›Full record

ReviewThe Lancet. Respiratory medicine2021

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease.

Davies Adeloye, Omer Elneima, Luke Daines, Krisnah Poinasamy, Jennifer K Quint, Samantha Walker, Chris E Brightling, Salman Siddiqui, John R Hurst, James D Chalmers and 8 more

Abstract readReviewConsensus Statement
In one paragraph

Review in The Lancet. Respiratory medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Physical activity promotion interventions in chronic airways disease: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
  4. Pooled it
  5. Prevalence, risk factors and treatments for post-COVID-19 breathlessness: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2022
    Pooled it
  6. Pooled it
  7. Guideline
  8. Trial
  9. Trial
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
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  18. Human microbiome in post-acute COVID-19 syndrome (PACS).Current research in microbial sciences · 2025
    Article
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  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Davies AdeloyeUsher Institute, University of Edinburgh, Edinburgh, UK.
Omer ElneimaThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Luke DainesUsher Institute, University of Edinburgh, Edinburgh, UK.
Krisnah PoinasamyAsthma UK and British Lung Foundation, London, UK.
Jennifer K QuintNational Heart & Lung Institute, Imperial College London, London, UK.
Samantha WalkerAsthma UK and British Lung Foundation, London, UK.
Chris E BrightlingThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Salman SiddiquiThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
John R HurstUCL Respiratory, University College London, London, UK.
James D ChalmersSchool of Medicine, University of Dundee, Dundee, UK.
Paul E PfefferBarts Health NHS Trust and Queen Mary University of London, London, UK.
Petr NovotnyThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Thomas M DrakeUsher Institute, University of Edinburgh, Edinburgh, UK.
Liam G HeaneyCentre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, N Ireland, UK.
Igor RudanUsher Institute, University of Edinburgh, Edinburgh, UK.
Aziz SheikhUsher Institute, University of Edinburgh, Edinburgh, UK.
Anthony De SoyzaPopulation Health Science Institute, NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle, UK. Electronic address: anthony.de-soyza@newcastle.ac.uk.
International COVID-19 Airways Diseases Group

Funding

Medical Research Council MC_PC_19004Medical Research Council MC_PC_19075Medical Research Council MR/V027859/1
6 · The paper itself

Abstract

Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.

Indexed as

Respiration DisordersCOVID-19HumansPost-Acute COVID-19 SyndromeResearchSARS-CoV-2

Identifiers

PMID34416191
PMCPMC8372501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.