ArticleCell host & microbe2021
A bacterial bile acid metabolite modulates T
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In one paragraph
Article in Cell host & microbe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 1 pooled it
17.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
202 citing papers in PubMed, 1 synthesis or guideline pooled it, 267 citations in OpenAlex.
- IBD-related inflammatory memory and colorectal cancer: epigenetic mechanisms and microbiome interventions.Frontiers in immunology · 2026Pooled it
- Gut microbiota shaping fatty liver disease progression.Life science alliance · 2027Review
- The role of gut microbes in production of aromatic carboxaldehydes.Gut microbes · 2026Article
- Protease-serpin-microbiome interactions in inflammatory bowel disease: toward integrated biomarkers of gut health.Gut microbes · 2026Review
- Unraveling the drug resistance web in IBD: The gut microbiota-immunity-epigenetics axis.Gut microbes · 2026Review
- The gut microbiome-bile acid-FXR interplay: a pivotal axis in metabolic and gastrointestinal diseases.Gut microbes · 2026Review
- A high-resolution spatial model of the primate gut microbiome defines niche-specific functions and host-adapted microbial metabolism.Gut microbes · 2026Article
- Pleiotropic roles of microbial bile acid metabolism in intestinal health and diseases.Cell host & microbe · 2026Review
- Microbial cues and T cell immunity: deciphering their interactions in chronic liver disease.Experimental & molecular medicine · 2026Review
- The urinary tract commensalApplied and environmental microbiology · 2026Article
- Intestinal uptake regulates T cell responses to dietary antigens.bioRxiv : the preprint server for biology · 2026Article
- Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases.Signal transduction and targeted therapy · 2026Review
- Bile acid sequestration reveals microbiome remodeling that dominates FXR signaling to shape host responses to enteric infection.PLoS pathogens · 2026Article
- Bile acid metabolism and signaling in human and animal health: A One Health perspective.iMetaOmics · 2026Review
- Gut Microbiota-Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1-Mediated Parthanatos.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Subclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapy.Cancer cell · 2026Article
- Comparative Metabolomics Reveals the Production of Sulfated Metabolites by Human Gut Bacteria.Journal of the American Chemical Society · 2026Article
- Specific bile acids can elicit the type-I interferon response through the cGAS-STING pathway.Cell communication and signaling : CCS · 2026Article
- Chenodeoxycholic acid redirects the bile acid synthetic pathway to limit pro-inflammatory neutrophil infiltration and alleviate colitis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- The Gut-Pancreas Axis in Type 1 Diabetes: Emerging Insights into Microbiota and Immune Interactions.International journal of molecular sciences · 2026Review
142 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 5 institutions in 2 countries.
Wei LiDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Saiyu HangDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Yuan FangDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Sena BaeDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Yancong ZhangDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Minghao ZhangTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Gang WangDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Megan D McCurryDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Munhyung BaeDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Donggi PaikDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Eric A FranzosaDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Fraydoon RastinejadTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Curtis HuttenhowerDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Lina YaoDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: lina_yao@hms.harvard.edu.
A Sloan DevlinDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address: sloan_devlin@hms.harvard.edu.
Jun R HuhDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: jun_huh@hms.harvard.edu.
Harvard University · USBoston VA Research Institute · USBroad Institute · USUniversity of Oxford · GBBrigham and Women's Hospital · US
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MBacterial metabolites controlling Th17 cellsR01DK110559 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HUH, JUN R. · 2016 to 2024
$5.1MHuman microbiome metabolites in health and diseaseR35GM128618 · NIGMS · HARVARD MEDICAL SCHOOL · PI Abigail Sloan Devlin · 2018 to 2026
$4.1MNIDDK NIH HHS P30 DK043351NIDDK NIH HHS R01 DK110559NIGMS NIH HHS R35 GM128618Wellcome Trust 210664/Z/18/Z
Abstract
Bile acids act as signaling molecules that regulate immune homeostasis, including the differentiation of CD4
Indexed as
BacteroidetesBile Acids and SaltsCell DifferentiationChromatinForkhead Transcription FactorsHumansInflammatory Bowel DiseasesMultigene FamilyNuclear Receptor Subfamily 4, Group A, Member 1PhenanthrenesPromoter Regions, GeneticSignal TransductionT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsBile Acids and SaltsChromatinForkhead Transcription FactorsFOXP3 protein, humanisoallolithocholic acidNR4A1 protein, humanNuclear Receptor Subfamily 4, Group A, Member 1Phenanthrenesbile acidshuman microbiomeinflammatory bowel diseaseT cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.