Evidence map›Paper›PMID 34416156›Full record

SynthesisAmerican journal of human genetics2021

Robust genetic nurture effects on education: A systematic review and meta-analysis based on 38,654 families across 8 cohorts.

Biyao Wang, Jessie R Baldwin, Tabea Schoeler, Rosa Cheesman, Wikus Barkhuizen, Frank Dudbridge, David Bann, Tim T Morris, Jean-Baptiste Pingault

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in American journal of human genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Indirect genetic effects of siblings.Journal of child psychology and psychiatry, and allied disciplines · 2026
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  6. Indirect Genetic Effects on Alcohol Use Disorder and Nicotine Dependence.medRxiv : the preprint server for health sciences · 2026
    Article
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Biyao WangDivision of Psychology and Language Sciences, University College London, London WC1H 0AP, UK.
Jessie R BaldwinDivision of Psychology and Language Sciences, University College London, London WC1H 0AP, UK; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London SE5 8AF, UK.
Tabea SchoelerDivision of Psychology and Language Sciences, University College London, London WC1H 0AP, UK.
Rosa CheesmanSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London SE5 8AF, UK; PROMENTA Research Center, Department of Psychology, University of Oslo, 0373 Oslo, Norway.
Wikus BarkhuizenDivision of Psychology and Language Sciences, University College London, London WC1H 0AP, UK.
Frank DudbridgeDepartment of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
David BannCentre for Longitudinal Studies, Social Research Institute, University College London, London WC1H 0AL, UK.
Tim T MorrisMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
Jean-Baptiste PingaultDivision of Psychology and Language Sciences, University College London, London WC1H 0AP, UK; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College, London SE5 8AF, UK. Electronic address: j.pingault@ucl.ac.uk.

Funding

Medical Research Council MR/V002147/1Wellcome TrustWellcome Trust 215917/Z/19/ZWellcome Trust 218641/Z/19/Z
6 · The paper itself

Abstract

Similarities between parents and offspring arise from nature and nurture. Beyond this simple dichotomy, recent genomic studies have uncovered "genetic nurture" effects, whereby parental genotypes influence offspring outcomes via environmental pathways rather than genetic transmission. Such genetic nurture effects also need to be accounted for to accurately estimate "direct" genetic effects (i.e., genetic effects on a trait originating in the offspring). Empirical studies have indicated that genetic nurture effects are particularly relevant to the intergenerational transmission of risk for child educational outcomes, which are, in turn, associated with major psychological and health milestones throughout the life course. These findings have yet to be systematically appraised across contexts. We conducted a systematic review and meta-analysis to quantify genetic nurture effects on educational outcomes. A total of 12 studies comprising 38,654 distinct parent(s)-offspring pairs or trios from 8 cohorts reported 22 estimates of genetic nurture effects. Genetic nurture effects on offspring's educational outcomes (β

Indexed as

Educational StatusGene-Environment InteractionInheritance PatternsParentsAdultChildCohort StudiesFamilyFemaleGenotypeHumansMalePhenotypeSocial Classeducational achievementeducational attainmentgenetic nurtureintergenerational transmissionmeta-analysis

Identifiers

PMID34416156
PMCPMC8456157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.