Evidence map›Paper›PMID 34416141›Full record

ArticleCell chemical biology2021

Stuck on UUUU: New splicing inhibitors enhance U2AF2-RNA binding.

Sierra L Love, Aaron A Hoskins

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sierra L LoveDepartment of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA; Graduate Training Program in Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Aaron A HoskinsGraduate Training Program in Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: ahoskins@wisc.edu.
University of Wisconsin–Madison · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
Mechanisms of Spliceosome Assembly and RegulationR35GM136261 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Aaron Andrew Hoskins · 2020 to 2026
$3.2M
NIGMS NIH HHS R35 GM136261NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

In this issue of Cell Chemical Biology, Chatrikhi et al. (2021) identify a small molecule that enhances U2AF2 association with RNA to block pre-mRNA splicing during early stages of spliceosome assembly. This provides a mechanism of splicing inhibition and a molecular tool for elucidating intron recognition and spliceosome assembly.

Indexed as

RNARNA SplicingSplicing Factor U2AFRNASplicing Factor U2AF

Identifiers

PMID34416141
OpenAlexW3193945701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.