Evidence map›Paper›PMID 34416106›Full record

ArticleACS applied materials & interfaces2021

Biodegradable Poly(lactic acid) Stabilized Nanoemulsions for the Treatment of Multidrug-Resistant Bacterial Biofilms.

Yavuz Oz, Ahmed Nabawy, Stefano Fedeli, Aarohi Gupta, Rui Huang, Amitav Sanyal, Vincent M Rotello

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
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  13. Dual antimicrobial-loaded biodegradable nanoemulsions for synergistic treatment of wound biofilms.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Article
  14. pH-responsive hierarchical HJournal of nanobiotechnology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yavuz OzDepartment of Chemistry, Bogazici University, Istanbul 34342, Turkey.ORCID https://orcid.org/0000-0002-3862-4420
Ahmed NabawyDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID https://orcid.org/0000-0001-6505-4606
Stefano FedeliDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Aarohi GuptaDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID https://orcid.org/0000-0003-1303-1159
Rui HuangDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID https://orcid.org/0000-0002-1535-9804
Amitav SanyalDepartment of Chemistry, Bogazici University, Istanbul 34342, Turkey.ORCID https://orcid.org/0000-0001-5122-8329
Vincent M RotelloDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID https://orcid.org/0000-0002-5184-5439

Funding

Engineered Polymer Nanoemulsions for Treatment of Wound Biofilm InfectionsR01AI134770 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Robin Patel, VINCENT M. ROTELLO · 2018 to 2026
$3.5M
NIAID NIH HHS R01 AI134770
6 · The paper itself

Abstract

Biofilm infections caused by multidrug-resistant (MDR) bacteria are an urgent global health threat. Incorporation of natural essential oils into biodegradable oil-in-water cross-linked polymeric nanoemulsions (X-NEs) provides effective eradication of MDR bacterial biofilms. The X-NE platform combines the degradability of functionalized poly(lactic acid) polymers with the antimicrobial activity of carvacrol (from oregano oil). These X-NEs exhibited effective penetration and killing of biofilms formed by pathogenic bacteria. Biofilm-fibroblast coculture models demonstrate that X-NEs selectively eliminate bacteria without harming mammalian cells, making them promising candidates for antibiofilm therapeutics.

Indexed as

AnimalsAnti-Bacterial AgentsBiofilmsCymenesDrug CarriersDrug Resistance, Multiple, BacterialEmulsionsGram-Negative BacteriaGram-Positive BacteriaMiceMicrobial Sensitivity TestsNIH 3T3 CellsPolyestersAnti-Bacterial AgentscarvacrolCymenesDrug CarriersEmulsionsPolyesterspoly(lactide)antimicrobialsbiodegradable polymersbiofilm infectionsmultidrug resistancenanoemulsions

Identifiers

PMID34416106
PMCPMC8573728

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.