ArticleJournal of cosmetic dermatology2022
Continuous clinical improvement of mild-to-moderate seborrheic dermatitis and rebalancing of the scalp microbiome using a selenium disulfide-based shampoo after an initial treatment with ketoconazole.
Article in Journal of cosmetic dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Clinical Severity and Outcome Measures in Seborrheic Dermatitis: A Systematic Review.Dermatology and therapy · 2026Pooled it
- Managing Malassezia species and related infections: new insights into recent natural and synthetic antifungal compounds and their mechanism of action.Molecular diversity · 2026Review
- In-vivo pilot study to assess a new plant-based cosmetic formulation containing Ziziphus joazeiro bark extract and Apium graveolens seed extract for the improvement of dandruff while enhancing scalp microbiome balance and barrier function in subjects with oily to dry sensitive scalps.International journal of cosmetic science · 2026Article
- The Scalp Microbiome-Hair Axis: Mechanisms and Therapeutic Translation.Research (Washington, D.C.) · 2026Review
- Clinical effects of a 0.5% selenium sulfide shampoo on dandruff and scalp microbiota in adolescents: a prospective single-arm clinical study.Frontiers in medicine · 2026Article
- A Selenium Disulfide-Based Shampoo Is Beneficial for Dandruff Management and Rebalancing the Scalp Microbiome of Subjects of Any Hair Type.Skin appendage disorders · 2025Article
- Efficacy and safety of selenium disulfide in seborrheic dermatitis: what RCTs tell us?Annals of medicine and surgery (2012) · 2025Article
- Scalp Microbiome Dynamics Can Contribute to the Clinical Effect of a Novel Antiseborrheic Dermatitis Shampoo Containing Patented Antifungal Actives: A Randomized Controlled Study.Dermatology and therapy · 2025Article
- A study on dermatologists' self-assessment of the efficacy of a 1% selenium disulfide-0.9% salicylic acid -based shampoo for scalp seborrheic dermatitis.Archives of dermatological research · 2025Article
- Child and Adult Seborrheic Dermatitis: A Narrative Review of the Current Treatment Landscape.Dermatology and therapy · 2025Review
- A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.Skin appendage disorders · 2024Article
- A bibliometric and visual analysis of the research status and hotspots of seborrheic dermatitis based on web of science.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Comparison of the Skin Microbiota in the Periocular Region between Patients with Inflammatory Skin Diseases and Healthy Participants: A Preliminary Study.Life (Basel, Switzerland) · 2024Article
- Scalp microbiome: a guide to better understanding scalp diseases and treatments.Archives of dermatological research · 2024Review
- Development and Validation of a Gas Chromatography-Mass Spectrometry Method for the Analysis of the Novel Plant-Based Substance with Antimicrobial Activity.Antibiotics (Basel, Switzerland) · 2023Article
- Comprehensive Study of Drug-Induced Pruritus Based on Adverse Drug Reaction Report Database.Pharmaceuticals (Basel, Switzerland) · 2023Article
- The Effects of Zinc Pyrithione and Selenium Disulfide Shampoos on the Lesion-free Period After Treatment in Patients with Seborrheic Dermatitis.The Journal of clinical and aesthetic dermatology · 2023Review
- Alteration in skin mycobiome due to atopic dermatitis and seborrheic dermatitis.Biophysics reviews · 2023Review
- Chemical Composition and Antimicrobial Potential of a Plant-Based Substance for the Treatment of Seborrheic Dermatitis.Pharmaceuticals (Basel, Switzerland) · 2023Article
- A multi-study analysis enables identification of potential microbial features associated with skin aging signs.Frontiers in aging · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveScalp seborrheic dermatitis (SD) is a chronic, relapsing, and inflammatory scalp disease. Studies indicate a global bacterial and fungal microbiota shift of scalp SD, as compared to healthy scalp. Ketoconazole and selenium disulfide (SeS
aimThe main objective of this study was to investigate the changes in the scalp microbiota diversity and counts in subjects with scalp SD during a two-phase treatment period. MATERIAL AND
methodsThe scalp microbiota and clinical efficacy were investigated in 68 subjects with mild-to-moderate scalp SD after an initial one-month treatment with 2% ketoconazole, and after a 2-month maintenance phase, either with a 1% SeS
resultsThirty one subjects in the active and 37 subjects in the vehicle group participated. Ketoconazole provided an improvement of clinical symptoms (adherent (-1.75 p < 0.05), non-adherent (-1.5, p < 0.05)) flakes and erythema (scores 1.67-0.93, p < 0.001), in an increased fungal diversity and in a significant (p < 0.005) decrease of Malassezia spp. SeS
conclusionSelenium disulfide provides an additional benefit on the scalp microbiota and in clinical symptoms of SD and dandruff after treatment with ketoconazole. The results confirm the role of Staphylococcus spp. in scalp SD and open possible perspectives for preventing relapses.
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Registered trials
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