ArticleThe Journal of clinical endocrinology and metabolism2022
Association of Maternal Total Cholesterol With SGA or LGA Birth at Term: the Japan Environment and Children's Study.
Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Maternal Nutrition During Pregnancy and Fetal Outcome, Short- and Long-Term Health Effects: A Narrative Review.Nutrients · 2026Review
- Lipid profile analysis during pregnancy and its association with adverse pregnancy outcomes: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Maternal and Cord Blood Lipids in Pregnant Women With Obesity and Their Impact on Neonatal and Placental Biometric Features.Obesity science & practice · 2025Article
- Maternal Birth Weight FromJournal of pregnancy · 2025Article
- Influence of maternal lipid levels on adverse pregnancy outcomes in women with gestational diabetes mellitus.Frontiers in endocrinology · 2025Article
- History of large-for-gestational-age birth is independently associated with subsequent gestational diabetes in Chinese multiparous women: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Association of maternal dietary cholesterol intake during the second and third trimesters of pregnancy and blood glucose and pregnancy outcome in women with gestational diabetes mellitus: a prospective cohort study.Frontiers in nutrition · 2024Article
- Association between maternal cholesterol level during pregnancy and placental weight and birthweight ratio: data from the Japan Environment and Children's Study.BMC pregnancy and childbirth · 2023Article
- Baseline Complete Blood Count and Chemistry Panel Profile from the Japan Environment and Children's Study (JECS).International journal of environmental research and public health · 2022Article
- The association between alteration of maternal lipid levels and birthweight at term: A within-family comparison.Frontiers in endocrinology · 2022Article
- High Maternal Total Cholesterol Is Associated With No-Catch-up Growth in Full-Term SGA Infants: The Japan Environment and Children's Study.Frontiers in endocrinology · 2022Article
- Higher Peripheral Cholesterol and a Positive Correlation With Risk for Large-For-Gestational-Age Neonates in Pre-Pregnancy Underweight Women.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
26 authors at 17 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextMaternal cholesterol is important for fetal development. Whether maternal serum total cholesterol (maternal TC) levels in midpregnancy are associated with small (SGA) or large (LGA) for gestational age independent of prepregnancy body mass index (BMI) and weight gain during pregnancy is inconclusive.
objectiveThis work aimed to prospectively investigate the association between maternal TC in midpregnancy and SGA or LGA.
methodsThe Japan Environment and Children's Study is a nationwide prospective birth cohort study in Japan. Participants in this study included 37 449 nondiabetic, nonhypertensive mothers with singleton birth at term without congenital abnormalities. Birth weight for gestational age less than the 10th percentile and greater than or equal to the 90th percentile were respectively defined as SGA and LGA by the Japanese neonatal anthropometric charts.
resultsThe mean gestational age at blood sampling was 22.7 ± 4.0 weeks. After adjustment for maternal age, sex of child, parity, weight gain during pregnancy, prepregnancy BMI, smoking, alcohol drinking, blood glucose levels, household income, and study areas, 1-SD decrement of maternal TC was linearly associated with SGA (odds ratio [OR]: 1.20; 95% CI, 1.15-1.25). In contrast, 1-SD increment of maternal TC was linearly associated with LGA (OR: 1.13; 95% CI, 1.09-1.16). Associations did not differ according to prepregnancy BMI and gestational weight gain (P for interaction > .20).
conclusionMaternal TC levels in midpregnancy were associated with SGA or LGA in a Japanese cohort. It may help to predict SGA and LGA. Favorable maternal lipid profiles for fetal development must be explored.
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