Evidence map›Paper›PMID 34415963›Full record

ArticlePloS one2021

Sex differences in total cholesterol of Vietnamese adults.

Nga Thi Thu Tran, Christopher Leigh Blizzard, Khue Ngoc Luong, Ngoc Le Van Ngoc Truong, Bao Quoc Tran, Petr Otahal, Mark R Nelson, Costan G Magnussen, Tan Van Bui, Velandai Srikanth and 6 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Nga Thi Thu TranMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Christopher Leigh BlizzardMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.ORCID 0000-0002-9541-6943
Khue Ngoc LuongMedical Services Administration, Ministry of Health of the Socialist Republic of Vietnam, Hanoi, Vietnam.
Ngoc Le Van Ngoc TruongMedical Services Administration, Ministry of Health of the Socialist Republic of Vietnam, Hanoi, Vietnam.
Bao Quoc TranMedical Services Administration, Ministry of Health of the Socialist Republic of Vietnam, Hanoi, Vietnam.
Petr OtahalMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Mark R NelsonMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Costan G MagnussenMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Tan Van BuiMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Velandai SrikanthDepartment of Medicine, Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Thuy Bich AuMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Son Thai HaMedical Services Administration, Ministry of Health of the Socialist Republic of Vietnam, Hanoi, Vietnam.
Hai Ngoc PhungMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Mai Hoang TranMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Michele CallisayaMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Seana GallMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.ORCID 0000-0002-5138-2526
University of Tasmania · AUMinistry of Health · VNMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe mid-life emergence of higher levels of total cholesterol (TC) for women than for men has been observed in different Western and Asian populations. The aim of this study was to investigate whether there is evidence of this in Vietnam and, if so, whether it can be explained by ageing, by body size and fatness, or by socio-demographic characteristics and behavioural factors.

methodsParticipants (n = 14706, 50.9% females) aged 25-64 years were selected by multi-stage stratified cluster sampling from eight provinces each representing one of the eight geographical regions of Vietnam. Measurements were made using the World Health Organization STEPS protocols. Linear regression was used to assess the independent contributions of potential explanatory factors to mean levels of TC. Data were analysed using complex survey methods.

resultsMen and women had similar mean levels of body mass index (BMI), and men had modestly higher mean levels of waist circumference (WC), in each 5-year age category. The mean TC of women increased more or less continuously across the age range but with a step-up at age 50 years to reach higher concentrations on average than those of their male counterparts. The estimated step-up was not eliminated by adjustment for anthropometric indices including BMI or WC, or by adjustment for socio-demographic characteristics or behavioural factors. The estimated step-up was least for women with the greatest weight.

conclusionThere is a marked step-up in TC at age 50 years for Vietnamese women that cannot be explained by their age, or by their body fatness or its distribution, or by their socio-demographic characteristics or behavioural factors, and which results in greater mean levels of TC for middle-aged women than for their male counterparts in Vietnam.

Indexed as

Body Mass IndexCholesterolAdultFemaleHumansMaleMiddle AgedSex FactorsSoutheast Asian PeopleVietnamWaist CircumferenceCholesterol

Identifiers

PMID34415963
PMCPMC8378708
OpenAlexW3195783877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.