ReviewPlastic and reconstructive surgery2021
Evidence-Based Wound Irrigation: Separating Fact from Fiction.
Review in Plastic and reconstructive surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Integrating Super-Oxidised Solutions into Multimodal Strategies for Orthopaedic Infection Prevention and Management.Cureus · 2025Review
- Six Evidence-based Recommendations for Perioperative Incisional Care in Plastic Surgery: A Narrative Review.Plastic and reconstructive surgery. Global open · 2025Article
- Strategies for Reducing Surgical Site Infections After Oral Cancer Resection and Free-flap Reconstruction.Plastic and reconstructive surgery. Global open · 2025Article
- Concentration of Povidone-Iodine Pocket Irrigation in Implant-Based Breast Surgery: A Scoping Review.Aesthetic plastic surgery · 2025Article
- Lunar dust dermatologic considerations for NASA's artemis program and the gateway space station: a narrative review.Archives of dermatological research · 2024Review
- Implant-based Breast Reconstruction Salvage with Negative Pressure Wound Therapy with Instillation: An Evaluation of Outcomes.Plastic and reconstructive surgery. Global open · 2024Article
- Diagnosis and Treatment of Perioperative Allergic Complications: A Practical Review.Plastic and reconstructive surgery. Global open · 2024Review
- Measures to Prevent Infection in Cardiac Implantable Electronic Device Replacements or Upgrades.Reviews in cardiovascular medicine · 2024Review
- Prevention and Treatment of Burn Scar Contracture: A Practical Review.Plastic and reconstructive surgery. Global open · 2024Review
- The safety and efficacy of neutral electrolyzed water solution for wound irrigation: post-market clinical follow-up study.Frontiers in drug safety and regulation · 2024Article
- Article
- Negative-Pressure Wound Therapy: What We Know and What We Need to Know.Advances in experimental medicine and biology · 2023Article
- Analysis of flow rate and pressure in syringe-based wound irrigation using Bernoulli's equation.Scientific reports · 2022Article
- It Is Time to Abandon Betadine Irrigation of Breast Implant Pockets.Annals of plastic surgery · 2022Article
- Practical Review of the Management of Animal Bites.Plastic and reconstructive surgery. Global open · 2021Review
Corrections and comments
- Commented on by
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryThe relationship between wound irrigation and healing has been recognized for centuries. However, there is little evidence and no official recommendations from any health care organization regarding best wound irrigation practices. This is the first review of wound irrigation that systematically summarizes the literature using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and distills the evidence into a practical format. In this comprehensive review, the authors outline the irrigation fluids and delivery methods used in the identified studies, analyze reported treatment outcomes, summarize irrigation effectiveness, and propose evidence-based guidelines to improve wound healing outcomes and enhance the consistency of wound irrigation. Thirty-one high-quality studies with a combined total of 61,808 patients were included. Based on the current evidence provided by this review, the authors propose the following guidelines: (1) acute soft-tissue wounds should receive continuous gravity flow irrigation with polyhexanide; (2) complex wounds should receive continuous negative-pressure wound therapy with instillation with polyhexanide; (3) infected wounds should receive continuous negative-pressure wound therapy with instillation with silver nitrate, polyhexanide, acetic acid, or povidone-iodine; (4) breast implant wounds should receive gravity lavage with povidone-iodine or antibiotics; and (5) surgical-site infection rates can be reduced with intraoperative povidone-iodine irrigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.