ReviewEuropean respiratory review : an official journal of the European Respiratory Society2021
Unravelling the mechanisms driving multimorbidity in COPD to develop holistic approaches to patient-centred care.
Review in European respiratory review : an official journal of the European Respiratory Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Definitions of early COPD and predictors for disease progression: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- A Systematic Literature Review of the Humanistic, Economic, Sociodemographic, and Environmental Burden Associated with Severe COPD.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- Modifiable risk factors that may be addressed in routine care to prevent progression to and extension of multimorbidity in people with COPD: a systematic literature review.BMJ open respiratory research · 2024Pooled it
- Unveiling alternate pathways for SARS-CoV-2 infection via extracellular vesicle-mediated transfer of ACE2 and TMPRSS2.Nature communications · 2026Article
- Projecting the 20-year healthcare resource burden of asthma and COPD multimorbidity: insights from Singapore for integrated chronic respiratory care in South-East Asia.NPJ primary care respiratory medicine · 2026Article
- Mitigating chronic respiratory disease through the lens of multimorbidity: the MARES mixed-methods study protocol.BMJ open · 2026Article
- Spatial Epidemiology of the Ischemic Heart Disease-Asthma Comorbidity: A Global Analysis of Burden Patterns, Risk Drivers, and a Composite Risk Index.Risk management and healthcare policy · 2026Article
- Healthcare Costs and Trends of Multimorbidity in COPD Patients: A Population-Based Study in Singapore.International journal of chronic obstructive pulmonary disease · 2026Article
- Global Research Trends in Comorbidity Between Chronic Obstructive Pulmonary Disease and Gastro-Oesophageal Reflux Disease: A Bibliometric Study.International journal of chronic obstructive pulmonary disease · 2026Review
- Comparison of the predictive performance of Cumulative Illness Rating Scale, Charlson Comorbidity Index and COMCOLD Index for moderate-to-severe exacerbations in elderly subjects with chronic obstructive pulmonary disease.Annals of medicine · 2025Observational
- Chronic obstructive pulmonary disease (COPD) and autoimmune diseases: unravelling complex interactions.Annals of medicine · 2025Review
- Associations of preserved ratio impaired spirometry with cardiometabolic comorbidities: a systematic review and meta-analysis.ERJ open research · 2025Article
- Efficacy of SGLT2 Inhibitors, GLP-1 Receptor Agonists, DPP-4 Inhibitors, and Sulfonylureas on Moderate-to-Severe COPD Exacerbations Among Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Comorbidity profiles in chronic obstructive pulmonary disease: a multicohort study.ERJ open research · 2025Article
- Definitions of early COPD and markers and tools for predicting progression: a systematic review protocol.BMJ open · 2025Article
- Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases.Nature communications · 2025Article
- Percentage of Discharged COPD Patients with Exclusion Criteria for Participation in Outpatient Pulmonary Rehabilitation.Journal of clinical medicine · 2025Article
- Triple regulation of oxidative-acetylation cycling pathways in COPD glucocorticoid resistance by HuaTanJiangQi capsules.3 Biotech · 2025Article
- Disease Onset and Burden in Patients With Chronic Bronchitis and COPD: A Real-World Evidence Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Structured Cardiac Assessment and Treatment Following Exacerbations of COPD (SCATECOPD): A Pilot Randomised Controlled Trial.Biomedicines · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COPD is a major cause of morbidity and mortality worldwide. Multimorbidity is common in COPD patients and a key modifiable factor, which requires timely identification and targeted holistic management strategies to improve outcomes and reduce the burden of disease.We discuss the use of integrative approaches, such as cluster analysis and network-based theory, to understand the common and novel pathobiological mechanisms underlying COPD and comorbid disease, which are likely to be key to informing new management strategies.Furthermore, we discuss the current understanding of mechanistic drivers to multimorbidity in COPD, including hypotheses such as multimorbidity as a result of shared common exposure to noxious stimuli (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.