Evidence map›Paper›PMID 34415648›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2022

The biomechanical disadvantage of dysplastic hips.

Michael D Harris, Molly C Shepherd, Ke Song, Brecca M M Gaffney, Travis J Hillen, Marcie Harris-Hayes, John C Clohisy

Open access · greenAbstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 35 citations in OpenAlex.

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  11. The Treatment of Hip Dysplasia in Adolescent Patients.Current reviews in musculoskeletal medicine · 2025
    Review
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  20. Clinical evaluation of the painful adolescent and young adult hip.Journal of the Pediatric Orthopaedic Society of North America · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michael D HarrisProgram in Physical Therapy, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0002-3475-819X
Molly C ShepherdProgram in Physical Therapy, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Ke SongDepartment of Mechanical Engineering and Materials Science, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0001-8987-2523
Brecca M M GaffneyDepartment of Mechanical Engineering, University of Colorado-Denver, Denver, Colorado, USA.
Travis J HillenDepartment of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Marcie Harris-HayesProgram in Physical Therapy, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0003-4274-1651
John C ClohisyDepartment of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Washington University in St. Louis · USUniversity of Denver · US

Funding

Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
DOCTORAL TRAINING PROGRAM IN MOVEMENT SCIENCET32HD007434 · NICHD · WASHINGTON UNIVERSITY · PI Michael D Harris, Catherine Lang · 1993 to 2026
$4.2M
Muscle Geometry and its Influence on Function in Patients with Developmental Dysplasia of the HipK01AR072072 · NIAMS · WASHINGTON UNIVERSITY · PI HARRIS, MICHAEL D · 2018 to 2022
$554k
Effects of Simulated Interventions on Hip Articular Cartilage Loading in Patients with Femoroacetabular Impingement and Developmental Dysplasia of the HipF32AR075349 · NIAMS · WASHINGTON UNIVERSITY · PI GAFFNEY, BRECCA · 2019 to 2020
$97k
NIAMS NIH HHS F32 AR075349NIAMS NIH HHS K01 AR072072NIAMS NIH HHS P30 AR074992NICHD NIH HHS T32 HD007434
6 · The paper itself

Abstract

Developmental dysplasia of the hip (DDH) is strongly associated with an increased risk for hip osteoarthritis. Skeletal deformities undeniably contribute to detrimental biomechanical loading in dysplastic hips, but cannot explain all types of damage and symptoms that patients with DDH experience. Characterizing the geometry and function of the muscles spanning the hip is a logical next step in our progression of knowledge about DDH pathomechanics. In this study, we compared skeletal geometry, muscle volumes, intramuscular fatty infiltration, moment arms, and isometric strength in patients with DDH (N = 20) to healthy controls (N = 15). Femoral coverage was significantly less in patients (p < 0.001, Cohen's d effect size = 2.2), femoral neck-shaft angles were larger (p = 0.001, d = 1.3), and hip joint centers (HJCs) were more lateral (p = 0.001, d = 1.3). These skeletal abnormalities were associated with smaller abductor muscle moment arms in patients with DDH (e.g., gluteus medius [GMED]: p = 0.001, d = 1.2). Patients with DDH also had larger GMED volumes (p = 0.02, d = 0.83), but no differences in fatty infiltration, compared to controls. Isometric strength of the hip abductors, extensors, and flexors was lower in patients, but not significantly different from controls. The abnormal skeletal geometry, lateralized HJC, and reduced muscle moment arms represent a chronic biomechanical disadvantage under which patients with DDH operate. This phenomenon causes increased demand on the abductor muscles and results in high medially and superiorly directed joint reaction forces, which can explain reports of superomedial femoral cartilage damage in patients. The abnormal muscle geometry and function, in context with abnormal skeletal structure, are likely strong, but underappreciated, contributors to damaging loads in DDH.

Indexed as

Hip Dislocation, CongenitalOsteoarthritis, HipBiomechanical PhenomenaFemurHip JointHumansMuscle, Skeletalbiomechanical disadvantagedevelopmental dysplasia of the hiphip biomechanicsmuscle moment armsmuscle volume

Identifiers

PMID34415648
PMCPMC8858333
OpenAlexW3193645649

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.