Evidence map›Paper›PMID 34415572›Full record

ArticleJournal of medical virology2022

Correlation between a quantitative anti-SARS-CoV-2 IgG ELISA and neutralization activity.

Ramona Dolscheid-Pommerich, Eva Bartok, Marcel Renn, Beate M Kümmerer, Bianca Schulte, Ricarda M Schmithausen, Birgit Stoffel-Wagner, Hendrik Streeck, Sandra Saschenbrecker, Katja Steinhagen and 1 more

Abstract read
In one paragraph

Article in Journal of medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed.

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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ramona Dolscheid-PommerichInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-1266-8003
Eva BartokInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0003-0556-1950
Marcel RennInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-0120-4035
Beate M KümmererInstitute of Virology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-9011-2764
Bianca SchulteInstitute of Virology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0003-1096-3751
Ricarda M SchmithausenInstitute for Hygiene and Public Health, University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-3736-8672
Birgit Stoffel-WagnerInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
Hendrik StreeckInstitute of Virology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-0335-6390
Sandra SaschenbreckerInstitute for Experimental Immunology, Affiliated to EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany.ORCID 0000-0002-4769-915X
Katja SteinhagenInstitute for Experimental Immunology, Affiliated to EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany.
Gunther HartmannInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.ORCID 0000-0003-1021-2018

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the current COVID-19 pandemic, a better understanding of the relationship between merely binding and functionally neutralizing antibodies is necessary to characterize protective antiviral immunity following infection or vaccination. This study analyzes the level of correlation between the novel quantitative EUROIMMUN Anti-SARS-CoV-2 QuantiVac ELISA (IgG) and a microneutralization assay. A panel of 123 plasma samples from a COVID-19 outbreak study population, preselected by semiquantitative anti-SARS-CoV-2 IgG testing, was used to assess the relationship between the novel quantitative ELISA (IgG) and a microneutralization assay. Binding IgG targeting the S1 antigen was detected in 106 (86.2%) samples using the QuantiVac ELISA, while 89 (72.4%) samples showed neutralizing antibody activity. Spearman's correlation analysis demonstrated a strong positive relationship between anti-S1 IgG levels and neutralizing antibody titers (r

Indexed as

AdolescentAdultAgedAged, 80 and overAntibodies, NeutralizingAntibodies, ViralChildChild, PreschoolCOVID-19COVID-19 Serological TestingEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GMaleMiddle AgedAntibodies, NeutralizingAntibodies, ViralImmunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19ELISAmicroneutralizationSARS-CoV-2

Identifiers

PMID34415572
PMCPMC8426838

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.