Evidence map›Paper›PMID 34415548›Full record

ArticleBiomolecular NMR assignments2021

Backbone and nearly complete side-chain chemical shift assignments reveal the human uncharacterized protein CXorf51A as intrinsically disordered.

Christoph Wiedemann, Kingsley Benjamin Obika, Sandra Liebscher, Jan Jirschitzka, Oliver Ohlenschlãger, Frank Bordusa

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Article in Biomolecular NMR assignments, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Christoph WiedemannCharles Tanford Protein Centre, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120, Halle, Germany. christoph.wiedemann@uni-jena.de.ORCID 0000-0003-4351-8857
Kingsley Benjamin ObikaCharles Tanford Protein Centre, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120, Halle, Germany.
Sandra LiebscherCharles Tanford Protein Centre, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120, Halle, Germany.ORCID 0000-0001-9582-8473
Jan JirschitzkaDepartment of Chemistry, Institute of Biochemistry, University of Cologne, Zülpicher Str. 47, 50674, Cologne, Germany.ORCID 0000-0003-1007-4700
Oliver OhlenschlãgerLeibniz Institute on Aging - Fritz Lipmann Institute, Beutenbergstr. 11, 07745, Jena, Germany.ORCID 0000-0002-6428-4423
Frank BordusaCharles Tanford Protein Centre, Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Str. 3a, 06120, Halle, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Even though the human genome project showed that our DNA contains a mere 20,000 to 25,000 protein coding genes, an unexpectedly large number of these proteins remain functionally uncharacterized. A structural characterization of these "unknown" proteins may help to identify possible cellular tasks. We therefore used a combination of bioinformatics and nuclear magnetic resonance spectroscopy to structurally de-orphanize one of these gene products, the 108 amino acid human uncharacterized protein CXorf51A. Both our bioinformatics analysis as well as the [Formula: see text]H, [Formula: see text]C, [Formula: see text]N backbone and near-complete side-chain chemical shift assignments indicate that it is an intrinsically disordered protein.

Indexed as

Intrinsically Disordered ProteinsNuclear Magnetic Resonance, BiomolecularAmino Acid SequenceHumansOpen Reading FramesProtein Structure, SecondaryIntrinsically Disordered ProteinsHuman proteinIDPIntrinsically disordered proteinNMRNuclear magnetic resonance spectroscopyResonance chemical shift assignmentStructural and functionalUncharacterized human protein

Identifiers

PMID34415548
PMCPMC8481210

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.