Evidence map›Paper›PMID 34415527›Full record

ArticleImmunologic research2021

Analysis of the dynamic changes in the proportion of immune cells and the proportion of cells with stem cell characteristics in the corresponding immune cell population of C57 mice during the natural aging process.

Jing Luan, Hao Xu, Zhang Jin, Hua Guan, Xingchun Gao, Xingchun Gou, Lixian Xu

Abstract read
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In one paragraph

Article in Immunologic research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jing Luan *Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China.ORCID http://orcid.org/0000-0003-2847-4606
Hao Xu *Institution of Basic Medical Science, Xi'an Medical University, Xi'an, China.
Zhang JinDepartment of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China.
Hua GuanShaanxi Key Laboratory of Ischemic Cardiovascular Disease, Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, China.
Xingchun GaoInstitution of Basic Medical Science, Xi'an Medical University, Xi'an, China.
Xingchun GouShaanxi Key Laboratory of Brain Disorders and Institute of Basic and Translational Medicine, Xi'an Medical University, Xi'an, 710021, Shaanxi, China. gouxingchun@189.cn.
Lixian XuDepartment of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China. xlx116@fmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aging of the immune system is not only an inevitable result but also an important cause of physical aging. The aging of the immune system is rooted in the aging of hematopoietic cells (HSCs), which manifests as decreasing functionality of the adaptive immune system and the innate immune system. C57BL/6 mice of different ages were collected in this study to better understand the changes in the structures of the innate and adaptive immune systems in individuals of different ages and the distribution and changes in immune cells with stem cell properties. The immune cells of the innate and adaptive immune systems, including DCs, monocytes, macrophages, CD4

Indexed as

AgingAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHematopoietic Stem CellsMiceAgingBiomarkersCD117HSCImmunosenescenceLy6A/E

Identifiers

PMID34415527

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.