Evidence map›Paper›PMID 34415509›Full record

ArticleCell biochemistry and biophysics2021

Lysophosphatidate Promotes Sphingosine 1-Phosphate Metabolism and Signaling: Implications for Breast Cancer and Doxorubicin Resistance.

Ganesh Venkatraman, Xiaoyun Tang, Guangwei Du, Amadeo M Parisentti, Denise G Hemmings, David N Brindley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Regulation for differential control.Nature chemical biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ganesh VenkatramanDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2S2, Canada.
Xiaoyun TangDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2S2, Canada.
Guangwei DuDepartment of Integrative Biology & Pharmacology, University of Texas Health Science at Houston, Houston, TX, 77030, USA.
Amadeo M ParisenttiNorthern Ontario School of Medicine, Health Sciences North Research Institute, Sudbury, ON, P3E 2H2, Canada.
Denise G HemmingsCancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB, T6G 2S2, Canada. denise.hemmings@ualberta.ca.
David N BrindleyDepartment of Biochemistry, University of Alberta, Edmonton, AB, T6G 2S2, Canada. david.brindley@ualberta.ca.ORCID http://orcid.org/0000-0003-2227-0020
University of Alberta · CAHealth Sciences North · CAThe University of Texas Health Science Center at Houston · US

Funding

american heart association 19TPA34910051American Heart Association-American Stroke Association 19TPA34910051
6 · The paper itself

Abstract

Lysophosphatidate (LPA) and sphingosine 1-phosphate (S1P) promote vasculogenesis, angiogenesis, and wound healing by activating a plethora of overlapping signaling pathways that stimulate mitogenesis, cell survival, and migration. As such, maladaptive signaling by LPA and S1P have major effects in increasing tumor progression and producing poor patient outcomes after chemotherapy and radiotherapy. Many signaling actions of S1P and LPA are not redundant; each are vital in normal physiology and their metabolisms differ. In the present work, we studied how LPA signaling impacts S1P metabolism and signaling in MDA-MB-231 and MCF-7 breast cancer cells. LPA increased sphingosine kinase-1 (SphK1) synthesis and rapidly activated cytosolic SphK1 through association with membranes. Blocking phospholipase D activity attenuated the LPA-induced activation of SphK1 and the synthesis of ABCC1 and ABCG2 transporters that secrete S1P from cells. This effect was magnified in doxorubicin-resistant MCF-7 cells. LPA also facilitated S1P signaling by increasing mRNA expression for S1P

Indexed as

ATP-Binding Cassette, Sub-Family C ProteinsBreast NeoplasmsDoxorubicinDrug Resistance, NeoplasmLysophospholipidsPhosphotransferases (Alcohol Group Acceptor)Signal TransductionSphingosineATP Binding Cassette Transporter, Subfamily G, Member 2Cell Line, TumorFemaleHumansMCF-7 CellsNeoplasm ProteinsReceptors, LysosphingolipidSphingosine KinaseABCG2 protein, humanATP-Binding Cassette, Sub-Family C ProteinsATP Binding Cassette Transporter, Subfamily G, Member 2Doxorubicinlysophosphatidic acidLysophospholipidsmultidrug resistance-associated protein 1Neoplasm ProteinsPhosphotransferases (Alcohol Group Acceptor)Receptors, LysosphingolipidSphingosinesphingosine 1-phosphateSphingosine KinaseAutotaxinInflammationLipid phosphate phosphatasesMultidrug resistance transporters

Identifiers

PMID34415509
PMCPMC11948428
OpenAlexW3193952483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.