Evidence map›Paper›PMID 34415396›Full record

ArticlePflugers Archiv : European journal of physiology2021

Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle.

Jae Mo Park, Sonal Josan, Ralph E Hurd, James Graham, Peter J Havel, David Bendahan, Dirk Mayer, Youngran Chung, Daniel M Spielman, Thomas Jue

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. DetectingFrontiers in physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Jae Mo ParkAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA.ORCID http://orcid.org/0000-0002-7404-6971
Sonal JosanDepartment of Radiology, Stanford University, 1201 Welch Rd., Stanford, CA, 94305, USA.
Ralph E HurdDepartment of Radiology, Stanford University, 1201 Welch Rd., Stanford, CA, 94305, USA.
James GrahamDepartment of Molecular Biosciences, University of California Davis, 3426 Meyer Hall, Davis, CA, 95616, USA.
Peter J HavelDepartment of Molecular Biosciences, University of California Davis, 3426 Meyer Hall, Davis, CA, 95616, USA.
David BendahanCNRS, Aix-Marseille University, CRMBM, 13385, Marseille, France.
Dirk MayerNeuroscience Program, SRI International, 333 Ravenswood Ave., Menlo Park, CA, 94025, USA.
Youngran ChungDepartment of Biochemistry and Molecular Medicine, University of California-Davis, 4323 Tupper Hall, Davis, CA, 95616, USA.
Daniel M SpielmanDepartment of Radiology, Stanford University, 1201 Welch Rd., Stanford, CA, 94305, USA.
Thomas JueDepartment of Biochemistry and Molecular Medicine, University of California-Davis, 4323 Tupper Hall, Davis, CA, 95616, USA. tjue@ucdavis.edu.ORCID http://orcid.org/0000-0003-1549-8414
University of California, Davis · USAdvanced Imaging Research (United States) · USApplied Sciences Laboratory (United States) · USCentre National de la Recherche Scientifique · FRSRI International · USStanford University · USUniversity of Maryland, Baltimore · US

Funding

CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISMR01AA005965 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF, ZAHR, NATALIE M · 1985 to 2025
$13.0M
Training and DisseminationP41EB015891 · NIBIB · STANFORD UNIVERSITY · PI GLOVER, GARY H · 2012 to 2019
$10.7M
CNS DEFICITS: INTERACTION OF AGE AND ALCOHOLISMR37AA005965 · NIAAA · STANFORD UNIVERSITY · PI PFEFFERBAUM, ADOLF · 1996 to 2005
$4.4M
Metabolic Therapy of GBM guided by MRS of hyperpolarized 13C-pyruvateR01CA176836 · NCI · STANFORD UNIVERSITY · PI RECHT, LAWRENCE D, SPIELMAN, DANIEL M · 2014 to 2018
$2.8M
Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolismR01NS107409 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PARK, JAE MO · 2020 to 2024
$2.7M
Hyperpolarizer for 13C MR Metabolic Imaging of Human Subjects and Animal ModelsS10OD012283 · OD · STANFORD UNIVERSITY · PI SPIELMAN, DANIEL M · 2013 to 2013
$2.0M
Metabolic imaging of nonalcoholic fatty liver diseaseR01DK106395 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2016 to 2019
$1.9M
Metabolic Imaging of the Cardioprotective Effects of Alcohol and ALDH2 ActivatorsR01AA018681 · NIAAA · STANFORD UNIVERSITY · PI SPIELMAN, DANIEL M · 2010 to 2013
$1.9M
Dynamic Metabolic Imaging of Hyperpolarized SubstratesR01EB009070 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2009 to 2012
$1.6M
Dissecting mechanisms by which GI surgery delays diabetes onset in UCD-T2DM ratsR01DK095960 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CUMMINGS, BETHANY PAIGE, HAVEL, PETER J · 2012 to 2015
$1.3M
Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondriaRC1DK087307 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GIULIVI, CECILIA, HAVEL, PETER J · 2009 to 2010
$985k
Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized 13C pyruvateR21NS096575 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2016 to 2017
$424k
NCI NIH HHS R01 CA176836NCI NIH HHS R21 CA213020NIAAA NIH HHS R01 AA005965NIAAA NIH HHS R01 AA018681NIAAA NIH HHS R37 AA005965NIBIB NIH HHS P41 EB015891NIBIB NIH HHS R01 EB009070NIDDK NIH HHS R01 DK095960NIDDK NIH HHS R01 DK106395NIDDK NIH HHS RC1 DK087307NIH HHS S10 OD012283NINDS NIH HHS R01 NS107409NINDS NIH HHS R21 NS096575
6 · The paper itself

Abstract

The role of pyruvate dehydrogenase in mediating lipid-induced insulin resistance stands as a central question in the pathogenesis of type 2 diabetes mellitus. Many researchers have invoked the Randle hypothesis to explain the reduced glucose disposal in skeletal muscle by envisioning an elevated acetyl CoA pool arising from increased oxidation of fatty acids. Over the years, in vivo NMR studies have challenged that monolithic view. The advent of the dissolution dynamic nuclear polarization NMR technique and a unique type 2 diabetic rat model provides an opportunity to clarify. Dynamic nuclear polarization enhances dramatically the NMR signal sensitivity and allows the measurement of metabolic kinetics in vivo. Diabetic muscle has much lower pyruvate dehydrogenase activity than control muscle, as evidenced in the conversion of [1-

Indexed as

Acetyl Coenzyme AAnimalsDiabetes Mellitus, Type 2Fatty AcidsGlucoseInsulin ResistanceMagnetic Resonance SpectroscopyMuscle, SkeletalMyocardiumOxidation-ReductionOxidoreductasesPyruvate Dehydrogenase Acetyl-Transferring KinasePyruvate Dehydrogenase ComplexPyruvic AcidRatsRats, Sprague-DawleyAcetyl Coenzyme AFatty AcidsGlucoseOxidoreductasesPyruvate Dehydrogenase Acetyl-Transferring KinasePyruvate Dehydrogenase ComplexPyruvic AcidDichloroacetateHyperpolarized NMRLactateMetabolismSkeletal muscleType 2 diabetes

Identifiers

PMID34415396
PMCPMC9219576
OpenAlexW3196143670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.