ArticleAmerican journal of physiology. Heart and circulatory physiology2021
MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca
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Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- Mitochondria-Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Mitoquinone Prevents Cardiac Dysfunction by Normalizing Mitochondrial ROS and Calcium Handling in Acute Myocardial Infarction.Acta physiologica (Oxford, England) · 2026Article
- Small-conductance CaThe Journal of physiology · 2026Review
- Long Noncoding RNA H19 Overexpression Inhibits High Glucose-Induced Oxidative Stress of Cardiomyocytes by Targeting MicroRNA-138-5p/MCU Axis: Implications for Diabetic Cardiomyopathy.Biochemical genetics · 2026Article
- Restoration of mitochondrial CaJournal of molecular and cellular cardiology · 2026Article
- Local calcium dynamics and signalling in cardiomyocytes.Nature reviews. Cardiology · 2026Review
- Alteration of Mitochondrial Ca2+ Fluxes by Kaempferol and CGP-37157 Regulates Ca2+ Oscillations in Human Alveolar Type 2 A549 Cells.Physiological research · 2026Article
- Mitochondrial Iron Handling and Lipid Peroxidation as Drivers of Ferroptosis.International journal of molecular sciences · 2026Review
- Mitochondrial calcium uniporter-mediated mitochondrial dynamics imbalance contributes to contrast medium-induced renal tubular cell injury.Frontiers in molecular biosciences · 2026Article
- Increased Intermembrane Space [CaCirculation research · 2025Article
- Sarcoplasmic reticulum-mitochondria microdomains: hugging and kissing in the heart.American journal of physiology. Cell physiology · 2025Review
- Pharmacological Enhancement of Small Conductance CaCirculation research · 2025Article
- Article
- Mitochondrial calcium uniporter complex: An emerging therapeutic target for cardiovascular diseases (Review).International journal of molecular medicine · 2025Review
- MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology.Journal of advanced research · 2025Review
- c-Src Is Responsible for Mitochondria-Mediated Arrhythmic Risk in Ischemic Cardiomyopathy.Circulation. Arrhythmia and electrophysiology · 2024Article
- Extracellular vesicles: opening up a new perspective for the diagnosis and treatment of mitochondrial dysfunction.Journal of nanobiotechnology · 2024Review
- Macrophage IL-1β mediates atrial fibrillation risk in diabetic mice.JCI insight · 2024Article
- Mitochondrial calcium uniporter deficiency in dentate granule cells remodels neuronal metabolism and impairs reversal learning.Journal of neurochemistry · 2024Article
- Diabetes cardiomyopathy: targeted regulation of mitochondrial dysfunction and therapeutic potential of plant secondary metabolites.Frontiers in pharmacology · 2024Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Shanna HamiltonDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.
Radmila TerentyevaDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.
Fruzsina PergerDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.
Benjamín Hernández OrengoDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.
Benjamin MartinDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.
Matthew W GorrDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.ORCID 0000-0001-7561-6481
Andriy E BelevychDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.
Richard T ClementsBiomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island.
Sandor GyörkeDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.
Dmitry TerentyevDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio.ORCID 0000-0002-9530-7384
The Ohio State University · USUniversity of Rhode Island · US
Funding
CONTROLLED AND UNCONTROLLABLE CALCIUM RELEASE IN HEARTR01HL063043 · NHLBI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI Sandor Gyorke · 1999 to 2026
$8.6MRyanodine Receptor Channels in Heart FailureR01HL074045 · NHLBI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI GYORKE, SANDOR · 2003 to 2024
$8.2MRegulation and Dysregulation of Cardiac EC coupling by CalmodulinR01HL138579 · NHLBI · OHIO STATE UNIVERSITY · PI Jonathan Paul Davis, Sandor Gyorke · 2017 to 2026
$6.1MNovel Mechanisms of Regulation of SK channels: Implications for Cardiac ArrhythmiaR01HL142588 · NHLBI · OHIO STATE UNIVERSITY · PI TERENTYEV, DMITRY A · 2019 to 2022
$2.4MREgulation of Calcium Homeostasis by MyomiRs in Heart FailureR01HL121796 · NHLBI · RHODE ISLAND HOSPITAL · PI TERENTYEV, DMITRY A · 2015 to 2019
$2.0MSurgical Cardioprotection Through BKCa-Dependent Modulation of Mitochondrial SupercomplexesR01HL135236 · NHLBI · UNIVERSITY OF RHODE ISLAND · PI CLEMENTS, RICHARD T · 2018 to 2021
$1.9MNHLBI NIH HHS R01 HL063043NHLBI NIH HHS R01 HL074045NHLBI NIH HHS R01 HL121796NHLBI NIH HHS R01 HL135236NHLBI NIH HHS R01 HL138579NHLBI NIH HHS R01 HL142588
Abstract
Cardiac dysfunction in heart failure (HF) and diabetic cardiomyopathy (DCM) is associated with aberrant intracellular Ca
Indexed as
Calcium SignalingAdrenergic beta-AgonistsAnimalsArrhythmias, CardiacBiosensing TechniquesCalciumCalcium ChannelsCells, CulturedDisease Models, AnimalHeart RateHypertrophy, Left VentricularMaleMicroscopy, ConfocalMitochondria, HeartMyocardial ContractionMyocytes, CardiacAdrenergic beta-AgonistsCalciumCalcium Channelsmitochondrial calcium uniporterReactive Oxygen Speciescalcium-dependent ventricular arrhythmiamitochondrial calcium uniportermitochondrial calcium uptakemitochondrial reactive oxygen speciesryanodine receptor
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.