ArticleAmerican journal of physiology. Heart and circulatory physiology2021
Cortical bone stem cells modify cardiac inflammation after myocardial infarction by inducing a novel macrophage phenotype.
Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Cardiac Macrophages Promote Polarization of Macrophages toward M2 Phenotype to Improve Myocardial Remodeling via NGAL after Myocardial Infarction.Cell biochemistry and biophysics · 2025Article
- Article
- The Dual Role of Macrophages in MIRI and MI by Immunity and Inflammation: Damage, Repair, Crosstalk, and Therapy.Mediators of inflammation · 2025Review
- Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives.Frontiers in immunology · 2024Article
- Development and Validation of a Novel Nomogram to Predict the Impact of the Polymorphisms of the Variants of ICAM-1 Gene on the Prognosis of Ischemic Cardiomyopathy.International journal of general medicine · 2023Article
- Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention.Frontiers in pharmacology · 2023Review
- Fibrin, Bone Marrow Cells and Macrophages Interactively Modulate Cardiomyoblast Fate.Biomedicines · 2022Article
- Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization duringFrontiers in immunology · 2022Article
- Development and validation of a predictive model of the impact of single nucleotide polymorphisms in theFrontiers in cardiovascular medicine · 2022Article
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
Acute damage to the heart, as in the case of myocardial infarction (MI), triggers a robust inflammatory response to the sterile injury that is part of a complex and highly organized wound-healing process. Cortical bone stem cell (CBSC) therapy after MI has been shown to reduce adverse structural and functional remodeling of the heart after MI in both mouse and swine models. The basis for these CBSC treatment effects on wound healing are unknown. The present experiments show that CBSCs secrete paracrine factors known to have immunomodulatory properties, most notably macrophage colony-stimulating factor (M-CSF) and transforming growth factor-β, but not IL-4. CBSC therapy increased the number of galectin-3
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