Evidence map›Paper›PMID 34415139›Full record

ReviewBioconjugate chemistry2021

Supramolecular "Click Chemistry" for Targeting in the Body.

Christopher J Addonizio, Brant D Gates, Matthew J Webber

Open access · greenAbstract readReview
In one paragraph

Review in Bioconjugate chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Click chemistry and drug delivery: A bird's-eye view.Acta pharmaceutica Sinica. B · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christopher J AddonizioUniversity of Notre Dame, Department of Chemical & Biomolecular Engineering, Notre Dame, Indiana 46556 United States.
Brant D GatesUniversity of Notre Dame, Department of Chemical & Biomolecular Engineering, Notre Dame, Indiana 46556 United States.
Matthew J WebberUniversity of Notre Dame, Department of Chemical & Biomolecular Engineering, Notre Dame, Indiana 46556 United States.ORCID 0000-0003-3111-6228
University of Notre Dame · US

Funding

Non-Covalent Molecular Recognition for Drug Targeting in the BodyR35GM137987 · NIGMS · UNIVERSITY OF NOTRE DAME · PI WEBBER, MATTHEW · 2020 to 2024
$2.2M
NIGMS NIH HHS R35 GM137987
6 · The paper itself

Abstract

The fields of precision imaging and drug delivery have revealed a number of tools to improve target specificity and increase efficacy in diagnosing and treating disease. Biological molecules, such as antibodies, continue to be the primary means of assuring active targeting of various payloads. However, molecular-scale recognition motifs have emerged in recent decades to achieve specificity through the design of interacting chemical motifs. In this regard, an assortment of bioorthogonal covalent conjugations offer possibilities for

Indexed as

Click ChemistryDrug Delivery SystemsAnimalsHumansOligonucleotidesPeptidesOligonucleotidesPeptides

Identifiers

PMID34415139
PMCPMC8764705
OpenAlexW3193334787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.