Evidence map›Paper›PMID 34415081›Full record

ArticleThe International journal of eating disorders2021

Use of high-frequency repetitive transcranial magnetic stimulation to probe the neural circuitry of food choice in anorexia nervosa: A proof-of-concept study.

Alexandra F Muratore, Mariya Bershad, Joanna E Steinglass, Karin E Foerde, Loren Gianini, Allegra Broft, Evelyn Attia

Open access · greenAbstract read
In one paragraph

Article in The International journal of eating disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. rTMS Therapy for Eating Disorders: Scoping Review on Efficacy, Safety, Stimulation Parameters and Study Subjects.European eating disorders review : the journal of the Eating Disorders Association · 2026
    Review
  7. Recent developments in treatments for eating disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alexandra F MuratoreDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-2546-1490
Mariya BershadDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA.
Joanna E SteinglassDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0001-8434-8212
Karin E FoerdeDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-5804-9312
Loren GianiniDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-0692-4322
Allegra BroftDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA.
Evelyn AttiaDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0002-5602-6491
Columbia University Irving Medical Center · US

Funding

Research Training in Biobehavioral Disturbances of Eating DisordersT32MH096679 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EVELYN ATTIA, B. TIMOTHY WALSH · 2013 to 2026
$2.4M
NIMH NIH HHS T32 MH096679
6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is used to modulate neural systems and provides the opportunity for experimental tests of hypotheses regarding mechanisms underlying anorexia nervosa (AN). The present pilot study has investigated whether high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) to a region of the right dorsolateral prefrontal cortex (DLPFC) might be associated with change in food selection among adult inpatients with AN. Ten women received one session of sham and one session of HF-rTMS targeting the right DLPFC while completing a computerized Food Choice Task. Compared to sham, HF-rTMS was associated with changes in food ratings and food choice: inpatients reported higher healthiness ratings of low- and high-fat foods and selected a significantly greater proportion of high-fat foods over a neutrally rated reference item while receiving HF-rTMS. Findings suggest that HF-rTMS to the right DLPFC was associated with a reduction of fat avoidance on a food choice task among inpatients with AN and provide additional support for the possibility that this region, and related neural circuits, may underlie restrictive food choice. Research using rTMS to experimentally test neural mechanisms is needed to elucidate the underpinnings of AN and supports the development of novel treatment targets.

Indexed as

Anorexia NervosaTranscranial Magnetic StimulationAdultFemaleFood PreferencesHumansPilot ProjectsPrefrontal Cortexanorexia nervosacaloric restrictionchoice behaviorfeeding and eating disordersfood preferencesmagnetic resonance imagingneuronavigationTMStranscranial magnetic stimulation

Identifiers

PMID34415081
PMCPMC9126092
OpenAlexW3194168991

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.