Evidence map›Paper›PMID 34414859›Full record

ArticleChannels (Austin, Tex.)2021

17β-Estradiol activates Cl

Meisheng Yu, Yuan Wei, Yanfang Zheng, Lili Yang, Long Meng, Jiawei Lin, Peisheng Xu, Sanaa Ahmed Nagi Abdu Mahdy, Linyan Zhu, Shuang Peng and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Channels (Austin, Tex.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Meisheng YuDepartment of Pathophysiology, Medical College, Jinan University, Guangzhou, China.
Yuan WeiCenter for Scientific Research and Institute of Exercise and Health, Guangzhou Sports University, Guangzhou, China.
Yanfang ZhengDepartment of Physiology, Medical College, The Zhuhai Campus of the Zunyi Medical University, Zhuhai, China.
Lili YangAcademic Affairs Office, Guangzhou Medical University, Guangzhou, China.
Long MengDepartment of Obstetrics, Shiyan Maternal and Child Health Hospital, Hubei, Shiyan, China.
Jiawei LinDepartment of Breast Surgery, The First People's Hospital of Foshan, Foshan, China.
Peisheng XuDepartment of Physiology, Medical College, Jinan University, Guangzhou, China.
Sanaa Ahmed Nagi Abdu MahdyDepartment of Physiology, Medical College, Jinan University, Guangzhou, China.
Linyan ZhuDepartment of Physiology, Medical College, Jinan University, Guangzhou, China.
Shuang PengDepartment of Pathophysiology, Medical College, Jinan University, Guangzhou, China.
Lixin ChenDepartment of Physiology, Medical College, Jinan University, Guangzhou, China.
Liwei WangDepartment of Physiology, Medical College, Jinan University, Guangzhou, China.
Jinan University · CNFirst People's Hospital of Foshan · CNGuangzhou Medical University · CNGuangzhou Sport University · CNPeople's Hospital of Shiyan · CNZunyi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estradiol regulates thyroid function, and chloride channels are involved in the regulation of thyroid function. However, little is known about the role of chloride channels in the regulation of thyroid functions by estrogen. In this study, the effects of estrogen on chloride channel activities in human thyroid Nthy-ori3-1 cells were therefore investigated using the whole cell patch-clamp technique. The results showed that the extracellular application of 17β-estradiol (E2) activated Cl

Indexed as

Estrogen Receptor alphaThyroid GlandChloride ChannelsChloridesEstradiolHumansChloride ChannelsChloridesEstradiolEstrogen Receptor alphaChloride channelsClC-3estrogenestrogen receptorthyroid

Identifiers

PMID34414859
PMCPMC8381838
OpenAlexW3194275344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.