Evidence map›Paper›PMID 34414696›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Functionalizing Collagen with Vessel-Penetrating Two-Photon Phosphorescence Probes: A New In Vivo Strategy to Map Oxygen Concentration in Tumor Microenvironment and Tissue Ischemia.

Cheng-Ham Wu, Kristina S Kisel, Muthu Kumar Thangavel, Yi-Ting Chen, Kai-Hsin Chang, Ming-Rung Tsai, Chia-Yu Chu, Yu-Fang Shen, Pei-Chun Wu, Zhiming Zhang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Cheng-Ham WuDepartment of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Kristina S KiselDepartment of Chemistry, University of Eastern Finland, Joensuu, 80101, Finland.
Muthu Kumar ThangavelDepartment of Chemistry, University of Eastern Finland, Joensuu, 80101, Finland.
Yi-Ting ChenDepartment of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Kai-Hsin ChangDepartment of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.ORCID 0000-0002-2433-844X
Ming-Rung TsaiDepartment of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Chia-Yu ChuDepartment of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, 10002, Taiwan.
Yu-Fang ShenDepartment of Bioinformatics and Medical Engineering, Asia University, Taichung City, 41354, Taiwan.
Pei-Chun WuInstitute of Translational Medicine, Faculty of Health Sciences, Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau, 999078, China.
Zhiming ZhangInstitute of Translational Medicine, Faculty of Health Sciences, Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau, 999078, China.
Tzu-Ming LiuInstitute of Translational Medicine, Faculty of Health Sciences, Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau, 999078, China.ORCID 0000-0003-4260-6169
Janne JänisDepartment of Chemistry, University of Eastern Finland, Joensuu, 80101, Finland.
Elena V GrachovaSt.-Petersburg State University, 7/9 Universitetskaya nab, St.-Petersburg, 199034, Russia.
Julia R ShakirovaSt.-Petersburg State University, 7/9 Universitetskaya nab, St.-Petersburg, 199034, Russia.
Sergey P TunikSt.-Petersburg State University, 7/9 Universitetskaya nab, St.-Petersburg, 199034, Russia.ORCID 0000-0002-9431-0944
Igor O KoshevoyDepartment of Chemistry, University of Eastern Finland, Joensuu, 80101, Finland.ORCID 0000-0003-4380-1302
Pi-Tai ChouDepartment of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.ORCID 0000-0002-8925-7747

Funding

Academy of Finland 317903Flagship ProgrammeMinistry of Science and Technology, TaiwanNational Health Research Institutes, Taiwan NHRI-EX105-10427EIPhotonics Research and Innovation 320166Russian Science Foundation 19-73-20055The Science and Technology Development Fund, Macau SAR 0011/2019/AKPThe Science and Technology Development Fund, Macau SAR 0120/2020/A3The Science and Technology Development Fund, Macau SAR 018/2017/A1The Science and Technology Development Fund, Macau SAR 122/2016/A3University of LouisvilleUniversity of Macau MYRG2018-00070-FHSUniversity of Macau MYRG2019-00022-FHS
6 · The paper itself

Abstract

The encapsulation and/or surface modification can stabilize and protect the phosphorescence bio-probes but impede their intravenous delivery across biological barriers. Here, a new class of biocompatible rhenium (Re

Indexed as

Blood VesselsCollagenHumansIridiumLuminescent AgentsMicroscopy, ConfocalNeoplasmsOxygenPhotonsRheniumTumor HypoxiaTumor MicroenvironmentCollagenIridiumLuminescent AgentsOxygenRheniumphosphorescence lifetime imaging microscopyphosphorescent oxygen sensorsReI diimine carbonyl complexestissue ischemiatumor hypoxiatwo-photon phosphorescence

Identifiers

PMID34414696
PMCPMC8529487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.