ArticleMolecular systems biology2021
Evaluating the Arrhenius equation for developmental processes.
Article in Molecular systems biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 128 citations in OpenAlex.
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- DynamicAtlas: a morphodynamic atlas for Drosophila development.Nature methods · 2026Article
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- Mechanistic origins of temperature scaling in the early embryonic cell cycle.Nature communications · 2025Article
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- In Vitro Evaluation of Bovine Pulp Dissolution Using Dual Rinse HEDP at Different Temperatures.European endodontic journal · 2025Article
- Beyond the heat shock pathway: Heat stress responses in Drosophila development.Developmental biology · 2025Review
- Reducing Cofilin dosage makes embryos resilient to heat stress.bioRxiv : the preprint server for biology · 2025Article
- Praseodymium-Doped CrMolecules (Basel, Switzerland) · 2024Article
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- Iron-Single-Atom Nanozyme with NIR Enhanced Catalytic Activities for Facilitating MRSA-Infected Wound Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A Heating and Cooling Stage With Fast Temporal Control for Biological Applications.IEEE open journal of engineering in medicine and biology · 2024Article
- Uncovering developmental time and tempo using deep learning.Nature methods · 2023Article
- Efficient Removal of Nitrate in Neutral Solution Using Zero-Valent Al Activated by Soaking.ACS omega · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The famous Arrhenius equation is well suited to describing the temperature dependence of chemical reactions but has also been used for complicated biological processes. Here, we evaluate how well the simple Arrhenius equation predicts complex multi-step biological processes, using frog and fruit fly embryogenesis as two canonical models. We find that the Arrhenius equation provides a good approximation for the temperature dependence of embryogenesis, even though individual developmental intervals scale differently with temperature. At low and high temperatures, however, we observed significant departures from idealized Arrhenius Law behavior. When we model multi-step reactions of idealized chemical networks, we are unable to generate comparable deviations from linearity. In contrast, we find the two enzymes GAPDH and β-galactosidase show non-linearity in the Arrhenius plot similar to our observations of embryonic development. Thus, we find that complex embryonic development can be well approximated by the simple Arrhenius equation regardless of non-uniform developmental scaling and propose that the observed departure from this law likely results more from non-idealized individual steps rather than from the complexity of the system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.